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dc.contributor.authorMenuet, C
dc.contributor.authorCazals, Y
dc.contributor.authorGestreau, C
dc.contributor.authorBorghgraef, P
dc.contributor.authorGielis, L
dc.contributor.authorDutschmann, M
dc.contributor.authorVan Leuven, F
dc.contributor.authorHilaire, G
dc.date.accessioned2020-12-16T01:36:33Z
dc.date.available2020-12-16T01:36:33Z
dc.date.issued2011-10-12
dc.identifierpii: PONE-D-11-13651
dc.identifier.citationMenuet, C., Cazals, Y., Gestreau, C., Borghgraef, P., Gielis, L., Dutschmann, M., Van Leuven, F. & Hilaire, G. (2011). Age-Related Impairment of Ultrasonic Vocalization in Tau.P301L Mice: Possible Implication for Progressive Language Disorders. PLOS ONE, 6 (10), https://doi.org/10.1371/journal.pone.0025770.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/254334
dc.description.abstractBACKGROUND: Tauopathies, including Alzheimer's Disease, are the most frequent neurodegenerative diseases in elderly people and cause various cognitive, behavioural and motor defects, but also progressive language disorders. For communication and social interactions, mice produce ultrasonic vocalization (USV) via expiratory airflow through the larynx. We examined USV of Tau.P301L mice, a mouse model for tauopathy expressing human mutant tau protein and developing cognitive, motor and upper airway defects. METHODOLOGY/PRINCIPAL FINDINGS: At age 4-5 months, Tau.P301L mice had normal USV, normal expiratory airflow and no brainstem tauopathy. At age 8-10 months, Tau.P301L mice presented impaired USV, reduced expiratory airflow and severe tauopathy in the periaqueductal gray, Kolliker-Fuse and retroambiguus nuclei. Tauopathy in these nuclei that control upper airway function and vocalization correlates well with the USV impairment of old Tau.P301L mice. CONCLUSIONS: In a mouse model for tauopathy, we report for the first time an age-related impairment of USV that correlates with tauopathy in midbrain and brainstem areas controlling vocalization. The vocalization disorder of old Tau.P301L mice could be, at least in part, reminiscent of language disorders of elderly suffering tauopathy.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAge-Related Impairment of Ultrasonic Vocalization in Tau.P301L Mice: Possible Implication for Progressive Language Disorders
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0025770
melbourne.affiliation.departmentPhysiology
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titlePLoS One
melbourne.source.volume6
melbourne.source.issue10
dc.rights.licenseCC BY
melbourne.elementsid1116163
melbourne.contributor.authorMENUET, CLEMENT
melbourne.contributor.authorDutschmann, Mathias
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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