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    Immunogenicity of the inactivated influenza vaccine in children who have undergone allogeneic haematopoietic stem cell transplant

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    Author
    Ryan, AL; Wadia, UD; Jacoby, P; Cheung, LC; Kerr, F; Fraser, C; Tapp, H; Mechinaud, F; Carolan, LA; Laurie, KL; ...
    Date
    2020-04-01
    Source Title
    Bone Marrow Transplantation
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Barr, Ian; Laurie, Karen; Mechinaud, Francoise; Carolan, Louise
    Affiliation
    Microbiology and Immunology
    University General
    Doherty Institute
    Metadata
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    Document Type
    Journal Article
    Citations
    Ryan, A. L., Wadia, U. D., Jacoby, P., Cheung, L. C., Kerr, F., Fraser, C., Tapp, H., Mechinaud, F., Carolan, L. A., Laurie, K. L., Barr, I. G., Blyth, C. C., Gottardo, N. G., Richmond, P. C. & Kotecha, R. S. (2020). Immunogenicity of the inactivated influenza vaccine in children who have undergone allogeneic haematopoietic stem cell transplant. BONE MARROW TRANSPLANTATION, 55 (4), pp.773-779. https://doi.org/10.1038/s41409-019-0728-5.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254347
    DOI
    10.1038/s41409-019-0728-5
    Open Access URL
    https://europepmc.org/articles/PMC7223911?pdf=render
    Abstract
    Influenza vaccination is recommended for children following allogeneic haematopoietic stem cell transplant (HSCT), however there is limited evidence regarding its benefit. A prospective multicentre study was conducted to evaluate the immunogenicity of the inactivated influenza vaccine in children who have undergone HSCT compared with healthy age-matched controls. Participants were vaccinated between 2013 and 2016 according to Australian guidelines. Influenza-specific hemagglutinin inhibition antibody titres were performed prior to each vaccination and 4 weeks following the final vaccination. A nasopharyngeal aspirate for influenza was performed on participants that developed influenza-like illness. There were 86 children recruited; 43 who had undergone HSCT and 43 controls. For the HSCT group, seroprotection and seroconversion rates were 81.4% and 60.5% for H3N2, 41.9% and 32.6% for H1N1, and 44.2% and 39.5% for B strain respectively. There was a significant geometric mean fold increase to the H3N2 (GMFI 5.80, 95% CI 3.68-9.14, p < 0.001) and B (GMFI 3.44, 95% CI 2.36-5.00, p = 0.048) strains. Serological response was superior in age-matched controls to all vaccine strains. There were no serious adverse events following vaccination. For children who underwent HSCT, incidence of laboratory-proven influenza infection was 2.3%. Overall, this study provides evidence to support annual inactivated influenza vaccine administration to children following HSCT.

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