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    Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment.

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    Author
    Hrusak, O; Kalina, T; Wolf, J; Balduzzi, A; Provenzi, M; Rizzari, C; Rives, S; Del Pozo Carlavilla, M; Alonso, MEV; Domínguez-Pinilla, N; ...
    Date
    2020-06
    Source Title
    European Journal of Cancer
    Publisher
    Elsevier BV
    University of Melbourne Author/s
    Wolf, Joshua
    Affiliation
    Paediatrics (RCH)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Hrusak, O., Kalina, T., Wolf, J., Balduzzi, A., Provenzi, M., Rizzari, C., Rives, S., Del Pozo Carlavilla, M., Alonso, M. E. V., Domínguez-Pinilla, N., Bourquin, J. -P., Schmiegelow, K., Attarbaschi, A., Grillner, P., Mellgren, K., van der Werff Ten Bosch, J., Pieters, R., Brozou, T., Borkhardt, A. ,... Schrappe, M. (2020). Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment.. Eur J Cancer, 132, pp.11-16. https://doi.org/10.1016/j.ejca.2020.03.021.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254353
    DOI
    10.1016/j.ejca.2020.03.021
    Open Access URL
    https://europepmc.org/articles/PMC7141482?pdf=render
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141482
    Abstract
    INTRODUCTION: Since the beginning of COVID-19 pandemic, it is known that the severe course of the disease occurs mostly among the elderly, whereas it is rare among children and young adults. Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Thus, there is concern that children treated for cancer may allso be at risk for an unfavourable course of infection. Along the same line, anecdotal information from Wuhan, China, mentioned a severe course of COVID-19 in a child treated for leukaemia. AIM AND METHODS: We made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. Respondents were asked by email to fill in a short Web-based survey. RESULTS: We received reports from 25 countries, where approximately 10,000 patients at risk are followed up. At the time of the survey, more than 200 of these children were tested, nine of whom were positive for COVID-19. Eight of the nine cases had asymptomatic to mild disease, and one was just diagnosed with COVID-19. We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19. CONCLUSION: Thus, even children receiving anticancer chemotherapy may have a mild or asymptomatic course of COVID-19. While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment.

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