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    On the probability of strain invasion in endemic settings: Accounting for individual heterogeneity and control in multi-strain dynamics

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    Author
    Meehan, MT; Cope, RC; McBryde, ES
    Date
    2020-02-21
    Source Title
    Journal of Theoretical Biology
    Publisher
    ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
    University of Melbourne Author/s
    McBryde, Emma
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Meehan, M. T., Cope, R. C. & McBryde, E. S. (2020). On the probability of strain invasion in endemic settings: Accounting for individual heterogeneity and control in multi-strain dynamics. JOURNAL OF THEORETICAL BIOLOGY, 487, https://doi.org/10.1016/j.jtbi.2019.110109.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254405
    DOI
    10.1016/j.jtbi.2019.110109
    Open Access URL
    https://europepmc.org/articles/PMC7094110?pdf=render
    Abstract
    Pathogen evolution is an imminent threat to global health that has warranted, and duly received, considerable attention within the medical, microbiological and modelling communities. Outbreaks of new pathogens are often ignited by the emergence and transmission of mutant variants descended from wild-type strains circulating in the community. In this work we investigate the stochastic dynamics of the emergence of a novel disease strain, introduced into a population in which it must compete with an existing endemic strain. In analogy with past work on single-strain epidemic outbreaks, we apply a branching process approximation to calculate the probability that the new strain becomes established. As expected, a critical determinant of the survival prospects of any invading strain is the magnitude of its reproduction number relative to that of the background endemic strain. Whilst in most circumstances this ratio must exceed unity in order for invasion to be viable, we show that differential control scenarios can lead to less-fit novel strains invading populations hosting a fitter endemic one. This analysis and the accompanying findings will inform our understanding of the mechanisms that have led to past instances of successful strain invasion, and provide valuable lessons for thwarting future drug-resistant strain incursions.

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