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dc.contributor.authorZimmermann, P
dc.contributor.authorCurtis, N
dc.date.accessioned2020-12-16T23:38:14Z
dc.date.available2020-12-16T23:38:14Z
dc.date.issued2020-05-01
dc.identifierpii: 00006454-202005000-00001
dc.identifier.citationZimmermann, P. & Curtis, N. (2020). Coronavirus Infections in Children Including COVID-19 An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 39 (5), pp.355-368. https://doi.org/10.1097/INF.0000000000002660.
dc.identifier.issn0891-3668
dc.identifier.urihttp://hdl.handle.net/11343/254431
dc.description.abstractCoronaviruses (CoVs) are a large family of enveloped, single-stranded, zoonotic RNA viruses. Four CoVs commonly circulate among humans: HCoV2-229E, -HKU1, -NL63 and -OC43. However, CoVs can rapidly mutate and recombine leading to novel CoVs that can spread from animals to humans. The novel CoVs severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012. The 2019 novel coronavirus (SARS-CoV-2) is currently causing a severe outbreak of disease (termed COVID-19) in China and multiple other countries, threatening to cause a global pandemic. In humans, CoVs mostly cause respiratory and gastrointestinal symptoms. Clinical manifestations range from a common cold to more severe disease such as bronchitis, pneumonia, severe acute respiratory distress syndrome, multi-organ failure and even death. SARS-CoV, MERS-CoV and SARS-CoV-2 seem to less commonly affect children and to cause fewer symptoms and less severe disease in this age group compared with adults, and are associated with much lower case-fatality rates. Preliminary evidence suggests children are just as likely as adults to become infected with SARS-CoV-2 but are less likely to be symptomatic or develop severe symptoms. However, the importance of children in transmitting the virus remains uncertain. Children more often have gastrointestinal symptoms compared with adults. Most children with SARS-CoV present with fever, but this is not the case for the other novel CoVs. Many children affected by MERS-CoV are asymptomatic. The majority of children infected by novel CoVs have a documented household contact, often showing symptoms before them. In contrast, adults more often have a nosocomial exposure. In this review, we summarize epidemiologic, clinical and diagnostic findings, as well as treatment and prevention options for common circulating and novel CoVs infections in humans with a focus on infections in children.
dc.languageEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.titleCoronavirus Infections in Children Including COVID-19 An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children
dc.typeJournal Article
dc.identifier.doi10.1097/INF.0000000000002660
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titleThe Pediatric Infectious Disease Journal
melbourne.source.volume39
melbourne.source.issue5
melbourne.source.pages355-368
melbourne.elementsid1448048
melbourne.openaccess.urlhttps://europepmc.org/articles/PMC7158880?pdf=render
melbourne.openaccess.statusPublished version
melbourne.contributor.authorCurtis, Richard
melbourne.contributor.authorZimmermann, Petra
dc.identifier.eissn1532-0987
melbourne.accessrightsAccess this item via the Open Access location


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