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dc.contributor.authorHicks, SM
dc.contributor.authorPohl, K
dc.contributor.authorNeeman, T
dc.contributor.authorMcNamara, HA
dc.contributor.authorParsons, KM
dc.contributor.authorHe, J-S
dc.contributor.authorAli, SA
dc.contributor.authorNazir, S
dc.contributor.authorRowntree, LC
dc.contributor.authorNguyen, THO
dc.contributor.authorKedzierska, K
dc.contributor.authorDoolan, DL
dc.contributor.authorVinuesa, CG
dc.contributor.authorCook, MC
dc.contributor.authorCoatsworth, N
dc.contributor.authorMyles, PS
dc.contributor.authorKurth, F
dc.contributor.authorSander, LE
dc.contributor.authorMann, GJ
dc.contributor.authorGruen, RL
dc.contributor.authorGeorge, AJ
dc.contributor.authorGardiner, EE
dc.contributor.authorCockburn, IA
dc.date.accessioned2020-12-16T23:40:52Z
dc.date.available2020-12-16T23:40:52Z
dc.date.issued2021-01-01
dc.identifierpii: 5917625
dc.identifier.citationHicks, S. M., Pohl, K., Neeman, T., McNamara, H. A., Parsons, K. M., He, J. -S., Ali, S. A., Nazir, S., Rowntree, L. C., Nguyen, T. H. O., Kedzierska, K., Doolan, D. L., Vinuesa, C. G., Cook, M. C., Coatsworth, N., Myles, P. S., Kurth, F., Sander, L. E., Mann, G. J. ,... Cockburn, I. A. (2021). A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting. JOURNAL OF INFECTIOUS DISEASES, 223 (1), pp.10-14. https://doi.org/10.1093/infdis/jiaa623.
dc.identifier.issn0022-1899
dc.identifier.urihttp://hdl.handle.net/11343/254463
dc.description.abstractEstimates of seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies have been hampered by inadequate assay sensitivity and specificity. Using an enzyme-linked immunosorbent assay-based approach that combines data about immunoglobulin G responses to both the nucleocapsid and spike receptor binding domain antigens, we show that excellent sensitivity and specificity can be achieved. We used this assay to assess the frequency of virus-specific antibodies in a cohort of elective surgery patients in Australia and estimated seroprevalence in Australia to be 0.28% (95% Confidence Interval, 0-1.15%). These data confirm the low level of transmission of SARS-CoV-2 in Australia before July 2020 and validate the specificity of our assay.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS INC
dc.titleA Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting
dc.typeJournal Article
dc.identifier.doi10.1093/infdis/jiaa623
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentClinical Pathology
melbourne.source.titleJournal of Infectious Diseases
melbourne.source.volume223
melbourne.source.issue1
melbourne.source.pages10-14
melbourne.elementsid1467459
melbourne.openaccess.urlhttps://europepmc.org/articles/PMC7665523?pdf=render
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665523
melbourne.openaccess.statusPublished version
melbourne.contributor.authorRowntree, Louise
melbourne.contributor.authorKedzierska, Katherine
melbourne.contributor.authorNguyen, Thi Hoang Oanh
melbourne.contributor.authorGeorge, Amee
dc.identifier.eissn1537-6613
melbourne.accessrightsAccess this item via the Open Access location


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