Show simple item record

dc.contributor.authorAgyeman, AA
dc.contributor.authorChin, KL
dc.contributor.authorLandersdorfer, CB
dc.contributor.authorLiew, D
dc.contributor.authorOfori-Asenso, R
dc.date.accessioned2020-12-16T23:42:35Z
dc.date.available2020-12-16T23:42:35Z
dc.date.issued2020-08-01
dc.identifierpii: S0025-6196(20)30546-2
dc.identifier.citationAgyeman, A. A., Chin, K. L., Landersdorfer, C. B., Liew, D. & Ofori-Asenso, R. (2020). Smell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis. MAYO CLINIC PROCEEDINGS, 95 (8), pp.1621-1631. https://doi.org/10.1016/j.mayocp.2020.05.030.
dc.identifier.issn0025-6196
dc.identifier.urihttp://hdl.handle.net/11343/254485
dc.description.abstractOBJECTIVE: To estimate the prevalence of olfactory and gustatory dysfunctions (OGDs) among patients infected with novel coronavirus disease 2019 (COVID-19). METHODS: A systematic review was conducted by searching MEDLINE, EMBASE, and the preprint server MedRxiv from their inception until May 11, 2020, using the terms anosmia or hyposmia or dysosmia or olfactory dysfunction or olfaction disorder or smell dysfunction or ageusia or hypogeusia or dysgeusia or taste dysfunction or gustatory dysfunction or neurological and COVID-19 or 2019 novel coronavirus or 2019-nCoV or SARS-CoV-2. The references of included studies were also manually screened. Only studies involving patients with diagnostic-confirmed COVID-19 infection were included. Random-effects meta-analysis was performed. RESULTS: Twenty-four studies with data from 8438 patients with test-confirmed COVID-19 infection from 13 countries were included. The pooled proportions of patients presenting with olfactory dysfunction and gustatory dysfunction were 41.0% (95% CI, 28.5% to 53.9%) and 38.2% (95% CI, 24.0% to 53.6%), respectively. Increasing mean age correlated with lower prevalence of olfactory (coefficient = -0.076; P=.02) and gustatory (coefficient = -0.073; P=.03) dysfunctions. There was a higher prevalence of olfactory dysfunctions with the use of objective measurements compared with self-reports (coefficient = 2.33; P=.01). No significant moderation of the prevalence of OGDs by sex was observed. CONCLUSION: There is a high prevalence of OGDs among patients infected with COVID-19. Routine screening for these conditions could contribute to improved case detection in the ongoing COVID-19 pandemic. However, to better inform population screening measures, further studies are needed to establish causality.
dc.languageEnglish
dc.publisherELSEVIER SCIENCE INC
dc.titleSmell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis
dc.typeJournal Article
dc.identifier.doi10.1016/j.mayocp.2020.05.030
melbourne.affiliation.departmentMedicine and Radiology
melbourne.affiliation.departmentMedical Education
melbourne.source.titleMayo Clinic Proceedings
melbourne.source.volume95
melbourne.source.issue8
melbourne.source.pages1621-1631
melbourne.elementsid1451636
melbourne.openaccess.urlhttps://europepmc.org/articles/PMC7275152?pdf=render
melbourne.openaccess.statusPublished version
melbourne.contributor.authorChin, Ken
melbourne.contributor.authorLiew, Danny
dc.identifier.eissn1942-5546
melbourne.accessrightsAccess this item via the Open Access location


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record