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dc.contributor.authorCirovic, B
dc.contributor.authorde Bree, LCJ
dc.contributor.authorGroh, L
dc.contributor.authorBlok, BA
dc.contributor.authorChan, J
dc.contributor.authorvan der Velden, WJFM
dc.contributor.authorBremmers, MEJ
dc.contributor.authorvan Crevel, R
dc.contributor.authorHandler, K
dc.contributor.authorPicelli, S
dc.contributor.authorSchulte-Schrepping, J
dc.contributor.authorKlee, K
dc.contributor.authorOosting, M
dc.contributor.authorKoeken, VACM
dc.contributor.authorvan Ingen, J
dc.contributor.authorLi, Y
dc.contributor.authorBenn, CS
dc.contributor.authorSchultze, JL
dc.contributor.authorJoosten, LAB
dc.contributor.authorCurtis, N
dc.contributor.authorNetea, MG
dc.contributor.authorSchlitzer, A
dc.identifierpii: S1931-3128(20)30296-1
dc.identifier.citationCirovic, B., de Bree, L. C. J., Groh, L., Blok, B. A., Chan, J., van der Velden, W. J. F. M., Bremmers, M. E. J., van Crevel, R., Handler, K., Picelli, S., Schulte-Schrepping, J., Klee, K., Oosting, M., Koeken, V. A. C. M., van Ingen, J., Li, Y., Benn, C. S., Schultze, J. L., Joosten, L. A. B. ,... Schlitzer, A. (2020). BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment. CELL HOST & MICROBE, 28 (2), pp.322-+.
dc.description.abstractInduction of trained immunity by Bacille-Calmette-Guérin (BCG) vaccination mediates beneficial heterologous effects, but the mechanisms underlying its persistence and magnitude remain elusive. In this study, we show that BCG vaccination in healthy human volunteers induces a persistent transcriptional program connected to myeloid cell development and function within the hematopoietic stem and progenitor cell (HSPC) compartment in the bone marrow. We identify hepatic nuclear factor (HNF) family members 1a and b as crucial regulators of this transcriptional shift. These findings are corroborated by higher granulocyte numbers in BCG-vaccinated infants, HNF1 SNP variants that correlate with trained immunity, and elevated serum concentrations of the HNF1 target alpha-1 antitrypsin. Additionally, transcriptomic HSPC remodeling was epigenetically conveyed to peripheral CD14+ monocytes, displaying an activated transcriptional signature three months after BCG vaccination. Taken together, transcriptomic, epigenomic, and functional reprogramming of HSPCs and peripheral monocytes is a hallmark of BCG-induced trained immunity in humans.
dc.publisherCELL PRESS
dc.titleBCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment
dc.typeJournal Article
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titleCell Host and Microbe
melbourne.openaccess.statusPublished version
melbourne.contributor.authorCurtis, Richard
melbourne.accessrightsAccess this item via the Open Access location

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