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dc.contributor.authorDavis, JS
dc.contributor.authorFerreira, D
dc.contributor.authorDenholm, JT
dc.contributor.authorTong, SYC
dc.date.accessioned2020-12-16T23:44:17Z
dc.date.available2020-12-16T23:44:17Z
dc.date.issued2020-06-27
dc.identifier.citationDavis, J. S., Ferreira, D., Denholm, J. T. & Tong, S. Y. C. (2020). Clinical trials for the prevention and treatment ofCOVID-19: current state of play. MEDICAL JOURNAL OF AUSTRALIA, 213 (2), pp.86-93. https://doi.org/10.5694/mja2.50673.
dc.identifier.issn0025-729X
dc.identifier.urihttp://hdl.handle.net/11343/254506
dc.description.abstractSince coronavirus disease 2019 (COVID-19) emerged in Wuhan, China in December 2019 and spread around the world, over 1100 clinical studies have been registered globally on clinical trials registries, including over 500 randomised controlled trials. Such rapid development and launch of clinical trials is impressive but presents challenges, including the potential for duplication and competition. There is currently no known effective treatment for COVID-19. In order to focus on those studies most likely to influence clinical practice, we summarise the 31 currently registered randomised trials with a target sample size of at least 1000 participants. We have grouped these trials into four categories: prophylaxis; treatment of outpatients with mild COVID-19; treatment of hospitalised patients with moderate COVID-19; and treatment of hospitalised patients with moderate or severe disease. The most common therapeutic agent being trialled currently is hydroxychloroquine (24 trials with potential sample size of over 25 000 participants), followed by lopinavir-ritonavir (seven trials) and remdesevir (five trials) There are many candidate drugs in pre-clinical and early phase development, and these form a pipeline for future large clinical trials if current candidate therapies prove ineffective or unsafe.
dc.languageEnglish
dc.publisherWILEY
dc.titleClinical trials for the prevention and treatment ofCOVID-19: current state of play
dc.typeJournal Article
dc.identifier.doi10.5694/mja2.50673
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentDoherty Institute
melbourne.source.titleMedical Journal of Australia
melbourne.source.volume213
melbourne.source.issue2
melbourne.source.pages86-93
melbourne.elementsid1455430
melbourne.openaccess.urlhttps://europepmc.org/articles/PMC7361919?pdf=render
melbourne.openaccess.statusPublished version
melbourne.contributor.authorTong, Steven
melbourne.contributor.authorDenholm, Justin
dc.identifier.eissn1326-5377
melbourne.accessrightsAccess this item via the Open Access location


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