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    Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?

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    Author
    Soliz, J; Schneider-Gasser, EM; Arias-Reyes, C; Aliaga-Raduan, F; Poma-Machicao, L; Zubieta-Calleja, G; Furuya, W; Trevizan-Bau, P; Dhingra, RR; Dutschmann, M
    Date
    2020-08-01
    Source Title
    Respiratory Physiology and Neurobiology
    Publisher
    ELSEVIER
    University of Melbourne Author/s
    Dutschmann, Mathias
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Soliz, J., Schneider-Gasser, E. M., Arias-Reyes, C., Aliaga-Raduan, F., Poma-Machicao, L., Zubieta-Calleja, G., Furuya, W., Trevizan-Bau, P., Dhingra, R. R. & Dutschmann, M. (2020). Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 279, https://doi.org/10.1016/j.resp.2020.103476.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254529
    DOI
    10.1016/j.resp.2020.103476
    Open Access URL
    https://europepmc.org/articles/PMC7275159?pdf=render
    Abstract
    A very recent epidemiological study provides preliminary evidence that living in habitats located at 2500 m above sea level (masl) might protect from the development of severe respiratory symptoms following infection with the novel SARS-CoV-2 virus. This epidemiological finding raises the question of whether physiological mechanisms underlying the acclimatization to high altitude identifies therapeutic targets for the effective treatment of severe acute respiratory syndrome pivotal to the reduction of global mortality during the COVID-19 pandemic. This article compares the symptoms of acute mountain sickness (AMS) with those of SARS-CoV-2 infection and explores overlapping patho-physiological mechanisms of the respiratory system including impaired oxygen transport, pulmonary gas exchange and brainstem circuits controlling respiration. In this context, we also discuss the potential impact of SARS-CoV-2 infection on oxygen sensing in the carotid body. Finally, since erythropoietin (EPO) is an effective prophylactic treatment for AMS, this article reviews the potential benefits of implementing FDA-approved erythropoietin-based (EPO) drug therapies to counteract a variety of acute respiratory and non-respiratory (e.g. excessive inflammation of vascular beds) symptoms of SARS-CoV-2 infection.

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