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    Cellular Interactions of Liposomes and PISA Nanoparticles during Human Blood Flow in a Microvascular Network

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    Author
    Vu, MN; Kelly, HG; Wheatley, AK; Peng, S; Pilkington, EH; Veldhuis, NA; Davis, TP; Kent, SJ; Truong, NP
    Date
    2020-06-25
    Source Title
    Small
    Publisher
    WILEY-V C H VERLAG GMBH
    University of Melbourne Author/s
    Kent, Stephen; Wheatley, Adam; Pilkington, Emily; Kelly, Hannah; Vu, Mai Ngoc
    Affiliation
    Microbiology and Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Vu, M. N., Kelly, H. G., Wheatley, A. K., Peng, S., Pilkington, E. H., Veldhuis, N. A., Davis, T. P., Kent, S. J. & Truong, N. P. (2020). Cellular Interactions of Liposomes and PISA Nanoparticles during Human Blood Flow in a Microvascular Network. SMALL, 16 (33), https://doi.org/10.1002/smll.202002861.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254534
    DOI
    10.1002/smll.202002861
    Open Access URL
    https://europepmc.org/articles/PMC7361276?pdf=render
    Abstract
    A key concept in nanomedicine is encapsulating therapeutic or diagnostic agents inside nanoparticles to prolong blood circulation time and to enhance interactions with targeted cells. During circulation and depending on the selected application (e.g., cancer drug delivery or immune modulators), nanoparticles are required to possess low or high interactions with cells in human blood and blood vessels to minimize side effects or maximize delivery efficiency. However, analysis of cellular interactions in blood vessels is challenging and is not yet realized due to the diverse components of human blood and hemodynamic flow in blood vessels. Here, the first comprehensive method to analyze cellular interactions of both synthetic and commercially available nanoparticles under human blood flow conditions in a microvascular network is developed. Importantly, this method allows to unravel the complex interplay of size, charge, and type of nanoparticles on their cellular associations under the dynamic flow of human blood. This method offers a unique platform to study complex interactions of any type of nanoparticles in human blood flow conditions and serves as a useful guideline for the rational design of liposomes and polymer nanoparticles for diverse applications in nanomedicine.

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