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    Constitutive immune mechanisms: mediators of host defence and immune regulation

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    Author
    Paludan, SR; Pradeu, T; Masters, SL; Mogensen, TH
    Date
    2020-08-11
    Source Title
    Nature Reviews Immunology
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Masters, Seth
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Paludan, S. R., Pradeu, T., Masters, S. L. & Mogensen, T. H. (2020). Constitutive immune mechanisms: mediators of host defence and immune regulation. NATURE REVIEWS IMMUNOLOGY, https://doi.org/10.1038/s41577-020-0391-5.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254542
    DOI
    10.1038/s41577-020-0391-5
    Open Access URL
    https://europepmc.org/articles/PMC7418297?pdf=render
    Abstract
    The immune system enables organisms to combat infections and to eliminate endogenous challenges. Immune responses can be evoked through diverse inducible pathways. However, various constitutive mechanisms are also required for immunocompetence. The inducible responses of pattern recognition receptors of the innate immune system and antigen-specific receptors of the adaptive immune system are highly effective, but they also have the potential to cause extensive immunopathology and tissue damage, as seen in many infectious and autoinflammatory diseases. By contrast, constitutive innate immune mechanisms, including restriction factors, basal autophagy and proteasomal degradation, tend to limit immune responses, with loss-of-function mutations in these pathways leading to inflammation. Although they function through a broad and heterogeneous set of mechanisms, the constitutive immune responses all function as early barriers to infection and aim to minimize any disruption of homeostasis. Supported by recent human and mouse data, in this Review we compare and contrast the inducible and constitutive mechanisms of immunosurveillance.

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