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dc.contributor.authorStephen, S
dc.contributor.authorPark, Y-A
dc.contributor.authorChrysostomou, A
dc.date.accessioned2020-12-16T23:48:42Z
dc.date.available2020-12-16T23:48:42Z
dc.date.issued2020-09-17
dc.identifier.citationStephen, S., Park, Y. -A. & Chrysostomou, A. (2020). Clinical benefits of Tocilizumab inCOVID-19-related cytokine release syndrome in a patient with end-stage kidney disease on haemodialysis in Australia. NEPHROLOGY, 25 (11), pp.845-849. https://doi.org/10.1111/nep.13767.
dc.identifier.issn1320-5358
dc.identifier.urihttp://hdl.handle.net/11343/254561
dc.description.abstractCOVID-19 remains a global pandemic with more than 10 million cases and half a million deaths worldwide. The disease manifestations in patients with chronic kidney disease and especially those on haemodialysis are still being understood, with only a few overseas case series, and small observational trials thus far. It appears that the disease is more severe in this patient cohort. Part of the pathophysiology of severe COVID-19 is related to accompanying cytokine release syndrome (CRS). Tocilizumab, an interleukin-6 inhibitor, has been trialled for treatment of CRS in COVID-19, but not yet approved. We present a case of an Australian patient on long-term haemodialysis with severe COVID-19 who was successfully treated with Tocilizumab. The peak of her illness was on day 7, with a C-reactive protein of 624 mg/L (reference < 5 mg/L), ferritin of 5293 ng/mL (reference 30-500 ng/mL), and interleukin-6 level 1959.7 pg/mL, consistent with CRS. She was severely hypoxic on a ventilator, with rising inotropic requirements. With the use of Tocilizumab, there was a significant and immediate response in her inflammatory markers, and she made a steady recovery. The patient was discharged home 6 weeks after presentation.
dc.languageEnglish
dc.publisherWILEY
dc.titleClinical benefits of Tocilizumab inCOVID-19-related cytokine release syndrome in a patient with end-stage kidney disease on haemodialysis in Australia
dc.typeJournal Article
dc.identifier.doi10.1111/nep.13767
melbourne.affiliation.departmentMedical Education
melbourne.source.titleNephrology
melbourne.source.volume25
melbourne.source.issue11
melbourne.source.pages845-849
melbourne.elementsid1461165
melbourne.openaccess.urlhttps://europepmc.org/articles/PMC7436382?pdf=render
melbourne.openaccess.statusPublished version
melbourne.contributor.authorChrysostomou, Anastasia
dc.identifier.eissn1440-1797
melbourne.accessrightsAccess this item via the Open Access location


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