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    Emergent Large Vessel Occlusion Stroke During New York City's COVID-19 Outbreak: Clinical Characteristics and Paraclinical Findings.

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    Author
    Majidi, S; Fifi, JT; Ladner, TR; Lara-Reyna, J; Yaeger, KA; Yim, B; Dangayach, N; Oxley, TJ; Shigematsu, T; Kummer, BR; ...
    Date
    2020-09
    Source Title
    Stroke
    Publisher
    Ovid Technologies (Wolters Kluwer Health)
    University of Melbourne Author/s
    Oxley, Thomas
    Affiliation
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Majidi, S., Fifi, J. T., Ladner, T. R., Lara-Reyna, J., Yaeger, K. A., Yim, B., Dangayach, N., Oxley, T. J., Shigematsu, T., Kummer, B. R., Stein, L. K., Weinberger, J., Fara, M. G., De Leacy, R., Dhamoon, M. S., Tuhrim, S. & Mocco, J. (2020). Emergent Large Vessel Occlusion Stroke During New York City's COVID-19 Outbreak: Clinical Characteristics and Paraclinical Findings.. Stroke, 51 (9), pp.2656-2663. https://doi.org/10.1161/STROKEAHA.120.030397.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/254570
    DOI
    10.1161/STROKEAHA.120.030397
    Open Access URL
    https://europepmc.org/articles/PMC7434004?pdf=render
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434004
    Abstract
    BACKGROUND AND PURPOSE: The 2019 novel coronavirus outbreak and its associated disease (coronavirus disease 2019 [COVID-19]) have created a worldwide pandemic. Early data suggest higher rate of ischemic stroke in severe COVID-19 infection. We evaluated whether a relationship exists between emergent large vessel occlusion (ELVO) and the ongoing COVID-19 outbreak. METHODS: This is a retrospective, observational case series. Data were collected from all patients who presented with ELVO to the Mount Sinai Health System Hospitals across New York City during the peak 3 weeks of hospitalization and death from COVID-19. Patients' demographic, comorbid conditions, cardiovascular risk factors, COVID-19 disease status, and clinical presentation were extracted from the electronic medical record. Comparison was made between COVID-19 positive and negative cohorts. The incidence of ELVO stroke was compared with the pre-COVID period. RESULTS: Forty-five consecutive ELVO patients presented during the observation period. Fifty-three percent of patients tested positive for COVID-19. Total patients' mean (±SD) age was 66 (±17). Patients with COVID-19 were significantly younger than patients without COVID-19, 59±13 versus 74±17 (odds ratio [95% CI], 0.94 [0.81-0.98]; P=0.004). Seventy-five percent of patients with COVID-19 were male compared with 43% of patients without COVID-19 (odds ratio [95% CI], 3.99 [1.12-14.17]; P=0.032). Patients with COVID-19 were less likely to be White (8% versus 38% [odds ratio (95% CI), 0.15 (0.04-0.81); P=0.027]). In comparison to a similar time duration before the COVID-19 outbreak, a 2-fold increase in the total number of ELVO was observed (estimate: 0.78 [95% CI, 0.47-1.08], P≤0.0001). CONCLUSIONS: More than half of the ELVO stroke patients during the peak time of the New York City's COVID-19 outbreak were COVID-19 positive, and those patients with COVID-19 were younger, more likely to be male, and less likely to be White. Our findings also suggest an increase in the incidence of ELVO stroke during the peak of the COVID-19 outbreak.

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