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dc.contributor.authorSogono, P
dc.contributor.authorBressel, M
dc.contributor.authorDavid, S
dc.contributor.authorShaw, M
dc.contributor.authorChander, S
dc.contributor.authorChu, J
dc.contributor.authorPlumridge, N
dc.contributor.authorByrne, K
dc.contributor.authorHardcastle, N
dc.contributor.authorKron, T
dc.contributor.authorWheeler, G
dc.contributor.authorHanna, GG
dc.contributor.authorMacManus, M
dc.contributor.authorBall, D
dc.contributor.authorSiva, S
dc.identifierpii: S0360-3016(20)34399-6
dc.identifier.citationSogono, P., Bressel, M., David, S., Shaw, M., Chander, S., Chu, J., Plumridge, N., Byrne, K., Hardcastle, N., Kron, T., Wheeler, G., Hanna, G. G., MacManus, M., Ball, D. & Siva, S. (2021). Safety, Efficacy, and Patterns of Failure After Single-Fraction Stereotactic Body Radiation Therapy (SBRT) for Oligometastases.. Int J Radiat Oncol Biol Phys, 109 (3), pp.756-763.
dc.description.abstractPURPOSE: Fewer attendances for radiation therapy results in increased efficiency and less foot traffic within a radiation therapy department. We investigated outcomes after single-fraction (SF) stereotactic body radiation therapy (SBRT) in patients with oligometastatic disease. METHODS AND MATERIALS: Between February 2010 and June 2019, patients who received SF SBRT to 1 to 5 sites of oligometastatic disease were included in this retrospective study. The primary objective was to describe patterns of first failure after SBRT. Secondary objectives included overall survival (OS), progression-free survival (PFS), high-grade treatment-related toxicity (Common Terminology Criteria for Adverse Events grade ≥3), and freedom from systemic therapy (FFST). RESULTS: In total, 371 patients with 494 extracranial oligometastases received SF SBRT ranging from 16 Gy to 28 Gy. The most common primary malignancies were prostate (n = 107), lung (n = 63), kidney (n = 52), gastrointestinal (n = 51), and breast cancers (n = 42). The median follow-up was 3.1 years. The 1-, 3-, and 5-year OS was 93%, 69%, and 55%, respectively; PFS was 48%, 19%, and 14%, respectively; and FFST was 70%, 43%, and 35%, respectively. Twelve patients (3%) developed grade 3 to 4 treatment-related toxicity, with no grade 5 toxicity. As the first site of failure, the cumulative incidence of local failure (irrespective of other failures) at 1, 3 and 5 years was 4%, 8%, and 8%, respectively; locoregional relapse at the primary was 10%, 18%, and 18%, respectively; and distant failure was 45%, 66%, and 70%, respectively. CONCLUSIONS: SF SBRT is safe and effective, and a significant proportion of patients remain FFST for several years after therapy. This approach could be considered in resource-constrained or bundled-payment environments. Locoregional failure of the primary site is the second most common pattern of failure, suggesting a role for optimization of primary control during metastasis-directed therapy.
dc.publisherElsevier BV
dc.titleSafety, Efficacy, and Patterns of Failure After Single-Fraction Stereotactic Body Radiation Therapy (SBRT) for Oligometastases.
dc.typeJournal Article
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.source.titleInternational Journal of Radiation: Oncology - Biology - Physics
melbourne.openaccess.statusPublished version
melbourne.contributor.authorKron, Tomas
melbourne.accessrightsAccess this item via the Open Access location

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