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dc.contributor.authorAung, AK
dc.contributor.authorAitken, T
dc.contributor.authorTeh, BM
dc.contributor.authorYu, C
dc.contributor.authorOfori-Asenso, R
dc.contributor.authorChin, KL
dc.contributor.authorLiew, D
dc.date.accessioned2020-12-16T23:53:36Z
dc.date.available2020-12-16T23:53:36Z
dc.date.issued2020-12-01
dc.identifierpii: S0163-4453(20)30708-8
dc.identifier.citationAung, A. K., Aitken, T., Teh, B. M., Yu, C., Ofori-Asenso, R., Chin, K. L. & Liew, D. (2020). Angiotensin converting enzyme genotypes and mortality from COVID-19: An ecological study. JOURNAL OF INFECTION, 81 (6), pp.961-965. https://doi.org/10.1016/j.jinf.2020.11.012.
dc.identifier.issn0163-4453
dc.identifier.urihttp://hdl.handle.net/11343/254621
dc.description.abstractBACKGROUND: Angiotensin converting enzyme (ACE) genotypes are known to be associated with development of acute respiratory distress syndrome (ARDS) and resultant mortality. In the present study, we examined the association between distribution frequency of ACE genotypes and COVID-19 mortality. METHODS: We undertook an ecological study to examine the association between ACE genotypes and COVID-19 mortality across 25 countries to represent different geographical regions of the world. The population frequencies of ACE genotypes were drawn from previously published reports and data on COVID-19-related mortality were extracted from 'Worldometer'. Multivariable analyses were also undertaken adjusting for age (median age), sex (percentage of females) and the number of COVID-19 tests undertaken. Associations between genotypes deletion/deletion (DD) and insertion/insertion (II) prevalence and COVID-19-related mortality (per million people per day since the first diagnosed case) were evaluated. RESULTS: The frequency of II genotype is highest in east Asian countries and lower among the European and African countries. An inverse geographical distribution frequency was noted for DD genotype. Increasing II genotype frequency was significantly associated with decreased COVID-19 mortality rates (adjusted incident rate ratio [IRR] 0.3, 95% confidence interval [CI]: 0.002-0.7, p = 0.03). However, no association was found between DD genotype frequency and COVID-19 mortality rates (adjusted IRR 4.3, 95% CI: 0.5-41.2, p = 0.2). CONCLUSIONS: Distribution frequency of ACE insertion/insertion (II) genotype may have a significant influence on COVID-19 mortality. This information has potential utility for resource planning at a systemic level, as well as for clinical management.
dc.languageEnglish
dc.publisherW B SAUNDERS CO LTD
dc.titleAngiotensin converting enzyme genotypes and mortality from COVID-19: An ecological study
dc.typeJournal Article
dc.identifier.doi10.1016/j.jinf.2020.11.012
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleJournal of Infection
melbourne.source.volume81
melbourne.source.issue6
melbourne.source.pages961-965
melbourne.elementsid1481993
melbourne.openaccess.urlhttps://europepmc.org/articles/PMC7666537?pdf=render
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666537
melbourne.openaccess.statusPublished version
melbourne.contributor.authorLiew, Danny
dc.identifier.eissn1532-2742
melbourne.accessrightsAccess this item via the Open Access location


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