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    Critical Role of Constitutive Type I Interferon Response in Bronchial Epithelial Cell to Influenza Infection

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    Author
    Hsu, AC-Y; Parsons, K; Barr, I; Lowther, S; Middleton, D; Hansbro, PM; Wark, PAB
    Date
    2012-03-02
    Source Title
    PLoS One
    Publisher
    PUBLIC LIBRARY SCIENCE
    University of Melbourne Author/s
    Barr, Ian
    Affiliation
    Microbiology and Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Hsu, A. C. -Y., Parsons, K., Barr, I., Lowther, S., Middleton, D., Hansbro, P. M. & Wark, P. A. B. (2012). Critical Role of Constitutive Type I Interferon Response in Bronchial Epithelial Cell to Influenza Infection. PLOS ONE, 7 (3), https://doi.org/10.1371/journal.pone.0032947.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254630
    DOI
    10.1371/journal.pone.0032947
    Abstract
    Innate antiviral responses in bronchial epithelial cells (BECs) provide the first line of defense against respiratory viral infection and the effectiveness of this response is critically dependent on the type I interferons (IFNs). However the importance of the antiviral responses in BECs during influenza infection is not well understood. We profiled the innate immune response to infection with H3N2 and H5N1 virus using Calu-3 cells and primary BECs to model proximal airway cells. The susceptibility of BECs to influenza infection was not solely dependent on the sialic acid-bearing glycoprotein, and antiviral responses that occurred after viral endocytosis was more important in limiting viral replication. The early antiviral response and apoptosis correlated with the ability to limit viral replication. Both viruses reduced RIG-I associated antiviral responses and subsequent induction of IFN-β. However it was found that there was constitutive release of IFN-β by BECs and this was critical in inducing late antiviral signaling via type I IFN receptors, and was crucial in limiting viral infection. This study characterizes anti-influenza virus responses in airway epithelial cells and shows that constitutive IFN-β release plays a more important role in initiating protective late IFN-stimulated responses during human influenza infection in bronchial epithelial cells.

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