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dc.contributor.authorVerma, S
dc.contributor.authorShakya, VPS
dc.contributor.authorIdnurm, A
dc.date.accessioned2020-12-17T02:52:38Z
dc.date.available2020-12-17T02:52:38Z
dc.date.issued2018-01-01
dc.identifier.citationVerma, S., Shakya, V. P. S. & Idnurm, A. (2018). Exploring and exploiting the connection between mitochondria and the virulence of human pathogenic fungi. VIRULENCE, 9 (1), pp.426-446. https://doi.org/10.1080/21505594.2017.1414133.
dc.identifier.issn2150-5594
dc.identifier.urihttp://hdl.handle.net/11343/254654
dc.description.abstractMitochondria are best known for their role in the production of ATP; however, recent research implicates other mitochondrial functions in the virulence of human pathogenic fungi. Inhibitors of mitochondrial succinate dehydrogenase or the electron transport chain are successfully used to combat plant pathogenic fungi, but similar inhibition of mitochondrial functions has not been pursued for applications in medical mycology. Advances in understanding mitochondrial function relevant to human pathogenic fungi are in four major directions: 1) the role of mitochondrial morphology in virulence, 2) mitochondrial genetics, with a focus on mitochondrial DNA recombination and mitochondrial inheritance 3) the role of mitochondria in drug resistance, and 4) the interaction of mitochondria with other organelles. Collectively, despite the similarities in mitochondrial functions between fungi and animals, this organelle is currently an under-explored potential target to treat medical mycoses. Future research could define and then exploit those mitochondrial components best suited as drug targets.
dc.languageEnglish
dc.publisherTAYLOR & FRANCIS INC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleExploring and exploiting the connection between mitochondria and the virulence of human pathogenic fungi
dc.typeJournal Article
dc.identifier.doi10.1080/21505594.2017.1414133
melbourne.affiliation.departmentSchool of BioSciences
melbourne.source.titleVirulence
melbourne.source.volume9
melbourne.source.issue1
melbourne.source.pages426-446
dc.rights.licenseCC BY
melbourne.elementsid1320940
melbourne.contributor.authorIdnurm, Alexander
dc.identifier.eissn2150-5608
melbourne.accessrightsOpen Access


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