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    Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure.

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    Author
    Glasner, C; van Timmeren, MM; Stobernack, T; Omansen, TF; Raangs, EC; Rossen, JW; de Goffau, MC; Arends, JP; Kampinga, GA; Koedijk, DGAM; ...
    Date
    2015-02-02
    Source Title
    Scientific Reports
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    OMANSEN, TILL
    Affiliation
    Microbiology and Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Glasner, C., van Timmeren, M. M., Stobernack, T., Omansen, T. F., Raangs, E. C., Rossen, J. W., de Goffau, M. C., Arends, J. P., Kampinga, G. A., Koedijk, D. G. A. M., Neef, J., Buist, G., Tavakol, M., van Wamel, W. J. B., Rutgers, A., Stegeman, C. A., Kallenberg, C. G. M., Heeringa, P. & van Dijl, J. M. (2015). Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure.. Sci Rep, 5 (1), pp.8188-. https://doi.org/10.1038/srep08188.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254672
    DOI
    10.1038/srep08188
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389034
    Abstract
    Chronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. To date, it was neither known whether GPA patients show similar humoral immune responses to S. aureus as healthy carriers, nor whether specific S. aureus types are associated with GPA. Therefore, this study was aimed at assessing humoral immune responses of GPA patients against S. aureus antigens in relation to the genetic diversity of their nasal S. aureus isolates. A retrospective cohort study was conducted, including 85 GPA patients and 18 healthy controls (HC). Humoral immune responses against S. aureus were investigated by determining serum IgG levels against 59 S. aureus antigens. Unexpectedly, patient sera contained lower anti-staphylococcal IgG levels than sera from HC, regardless of the patients' treatment, while total IgG levels were similar or higher. Furthermore, 210 S. aureus isolates obtained from GPA patients were characterized by different typing approaches. This showed that the S. aureus population of GPA patients is highly diverse and mirrors the general S. aureus population. Our combined findings imply that GPA patients are less capable of mounting a potentially protective antibody response to S. aureus than healthy individuals.

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