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dc.contributor.authorGlasner, C
dc.contributor.authorvan Timmeren, MM
dc.contributor.authorStobernack, T
dc.contributor.authorOmansen, TF
dc.contributor.authorRaangs, EC
dc.contributor.authorRossen, JW
dc.contributor.authorde Goffau, MC
dc.contributor.authorArends, JP
dc.contributor.authorKampinga, GA
dc.contributor.authorKoedijk, DGAM
dc.contributor.authorNeef, J
dc.contributor.authorBuist, G
dc.contributor.authorTavakol, M
dc.contributor.authorvan Wamel, WJB
dc.contributor.authorRutgers, A
dc.contributor.authorStegeman, CA
dc.contributor.authorKallenberg, CGM
dc.contributor.authorHeeringa, P
dc.contributor.authorvan Dijl, JM
dc.date.accessioned2020-12-17T02:55:07Z
dc.date.available2020-12-17T02:55:07Z
dc.date.issued2015-02-02
dc.identifierpii: srep08188
dc.identifier.citationGlasner, C., van Timmeren, M. M., Stobernack, T., Omansen, T. F., Raangs, E. C., Rossen, J. W., de Goffau, M. C., Arends, J. P., Kampinga, G. A., Koedijk, D. G. A. M., Neef, J., Buist, G., Tavakol, M., van Wamel, W. J. B., Rutgers, A., Stegeman, C. A., Kallenberg, C. G. M., Heeringa, P. & van Dijl, J. M. (2015). Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure. SCIENTIFIC REPORTS, 5 (1), https://doi.org/10.1038/srep08188.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/254672
dc.description.abstractChronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. To date, it was neither known whether GPA patients show similar humoral immune responses to S. aureus as healthy carriers, nor whether specific S. aureus types are associated with GPA. Therefore, this study was aimed at assessing humoral immune responses of GPA patients against S. aureus antigens in relation to the genetic diversity of their nasal S. aureus isolates. A retrospective cohort study was conducted, including 85 GPA patients and 18 healthy controls (HC). Humoral immune responses against S. aureus were investigated by determining serum IgG levels against 59 S. aureus antigens. Unexpectedly, patient sera contained lower anti-staphylococcal IgG levels than sera from HC, regardless of the patients' treatment, while total IgG levels were similar or higher. Furthermore, 210 S. aureus isolates obtained from GPA patients were characterized by different typing approaches. This showed that the S. aureus population of GPA patients is highly diverse and mirrors the general S. aureus population. Our combined findings imply that GPA patients are less capable of mounting a potentially protective antibody response to S. aureus than healthy individuals.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleLow anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure
dc.typeJournal Article
dc.identifier.doi10.1038/srep08188
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleScientific Reports
melbourne.source.volume5
melbourne.source.issue1
melbourne.source.pages8188-
dc.rights.licenseCC BY
melbourne.elementsid1220404
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389034
melbourne.contributor.authorOMANSEN, TILL
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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