University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Microbiology & Immunology
  • Microbiology & Immunology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Microbiology & Immunology
  • Microbiology & Immunology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Topography of distinct Staphylococcus aureus types in chronic wounds of patients with epidermolysis bullosa.

    Thumbnail
    Download
    Published version (1.465Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    14
    10
    Author
    van der Kooi-Pol, MM; Sadaghian Sadabad, M; Duipmans, JC; Sabat, AJ; Stobernack, T; Omansen, TF; Westerhout-Pluister, GN; Jonkman, MF; Harmsen, HJM; van Dijl, JM
    Date
    2013
    Source Title
    PLoS One
    Publisher
    Public Library of Science (PLoS)
    University of Melbourne Author/s
    OMANSEN, TILL
    Affiliation
    Microbiology and Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    van der Kooi-Pol, M. M., Sadaghian Sadabad, M., Duipmans, J. C., Sabat, A. J., Stobernack, T., Omansen, T. F., Westerhout-Pluister, G. N., Jonkman, M. F., Harmsen, H. J. M. & van Dijl, J. M. (2013). Topography of distinct Staphylococcus aureus types in chronic wounds of patients with epidermolysis bullosa.. PLoS One, 8 (6), pp.e67272-. https://doi.org/10.1371/journal.pone.0067272.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254673
    DOI
    10.1371/journal.pone.0067272
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692413
    Abstract
    The opportunistic pathogen Staphylococcus aureus is known to interfere with wound healing and represents a significant risk factor for wound infections and invasive disease. It is generally assumed that one individual is predominantly colonized by one S. aureus type. Nevertheless, patients with the genetic blistering disease epidermolysis bullosa (EB) often carry multiple S. aureus types. We therefore investigated whether different S. aureus types are present in individual wounds of EB patients and, if so, how they are spatially distributed. The staphylococcal topography in chronic wounds was mapped by replica-plating of used bandages and subsequent typing of S. aureus isolates. Individual chronic wounds of five patients contained up to six different S. aureus types. Unexpectedly, distinct S. aureus types formed micro-colonies that were located in close proximity and sometimes even overlapped. While some adjacent S. aureus isolates were closely related, others belonged to distinct molecular complexes. We conclude that the general assumption that one individual is predominantly colonized by one type of S. aureus does not apply to chronic wounds of EB patients. We consider this observation important, not only for EB patients, but also for other patients with chronic wounds in view of the potential risk for severe staphylococcal infections.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [53039]
    • Microbiology & Immunology - Research Publications [2207]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors