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dc.contributor.authorvan der Kooi-Pol, MM
dc.contributor.authorSadaghian Sadabad, M
dc.contributor.authorDuipmans, JC
dc.contributor.authorSabat, AJ
dc.contributor.authorStobernack, T
dc.contributor.authorOmansen, TF
dc.contributor.authorWesterhout-Pluister, GN
dc.contributor.authorJonkman, MF
dc.contributor.authorHarmsen, HJM
dc.contributor.authorvan Dijl, JM
dc.date.accessioned2020-12-17T02:55:19Z
dc.date.available2020-12-17T02:55:19Z
dc.date.issued2013
dc.identifierpii: PONE-D-13-07681
dc.identifier.citationvan der Kooi-Pol, M. M., Sadaghian Sadabad, M., Duipmans, J. C., Sabat, A. J., Stobernack, T., Omansen, T. F., Westerhout-Pluister, G. N., Jonkman, M. F., Harmsen, H. J. M. & van Dijl, J. M. (2013). Topography of distinct Staphylococcus aureus types in chronic wounds of patients with epidermolysis bullosa.. PLoS One, 8 (6), pp.e67272-. https://doi.org/10.1371/journal.pone.0067272.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/254673
dc.description.abstractThe opportunistic pathogen Staphylococcus aureus is known to interfere with wound healing and represents a significant risk factor for wound infections and invasive disease. It is generally assumed that one individual is predominantly colonized by one S. aureus type. Nevertheless, patients with the genetic blistering disease epidermolysis bullosa (EB) often carry multiple S. aureus types. We therefore investigated whether different S. aureus types are present in individual wounds of EB patients and, if so, how they are spatially distributed. The staphylococcal topography in chronic wounds was mapped by replica-plating of used bandages and subsequent typing of S. aureus isolates. Individual chronic wounds of five patients contained up to six different S. aureus types. Unexpectedly, distinct S. aureus types formed micro-colonies that were located in close proximity and sometimes even overlapped. While some adjacent S. aureus isolates were closely related, others belonged to distinct molecular complexes. We conclude that the general assumption that one individual is predominantly colonized by one type of S. aureus does not apply to chronic wounds of EB patients. We consider this observation important, not only for EB patients, but also for other patients with chronic wounds in view of the potential risk for severe staphylococcal infections.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.titleTopography of distinct Staphylococcus aureus types in chronic wounds of patients with epidermolysis bullosa.
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0067272
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titlePLoS One
melbourne.source.volume8
melbourne.source.issue6
melbourne.source.pagese67272-
dc.rights.licenseCC BY
melbourne.elementsid1220408
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692413
melbourne.contributor.authorOMANSEN, TILL
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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