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    Pathprinting: An integrative approach to understand the functional basis of disease

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    Author
    Altschuler, GM; Hofmann, O; Kalatskaya, I; Payne, R; Sui, SJH; Saxena, U; Krivtsov, AV; Armstrong, SA; Cai, T; Stein, L; ...
    Date
    2013-07-26
    Source Title
    Genome Medicine: medicine in the post-genomic era
    Publisher
    BMC
    University of Melbourne Author/s
    Hofmann, Oliver
    Affiliation
    Clinical Pathology
    Metadata
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    Document Type
    Journal Article
    Citations
    Altschuler, G. M., Hofmann, O., Kalatskaya, I., Payne, R., Sui, S. J. H., Saxena, U., Krivtsov, A. V., Armstrong, S. A., Cai, T., Stein, L. & Hide, W. A. (2013). Pathprinting: An integrative approach to understand the functional basis of disease. GENOME MEDICINE, 5 (7), https://doi.org/10.1186/gm472.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254679
    DOI
    10.1186/gm472
    Abstract
    New strategies to combat complex human disease require systems approaches to biology that integrate experiments from cell lines, primary tissues and model organisms. We have developed Pathprint, a functional approach that compares gene expression profiles in a set of pathways, networks and transcriptionally regulated targets. It can be applied universally to gene expression profiles across species. Integration of large-scale profiling methods and curation of the public repository overcomes platform, species and batch effects to yield a standard measure of functional distance between experiments. We show that pathprints combine mouse and human blood developmental lineage, and can be used to identify new prognostic indicators in acute myeloid leukemia. The code and resources are available at http://compbio.sph.harvard.edu/hidelab/pathprint.

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