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    Using Animal Models to Study the Role of the Gut-Brain Axis in Autism.

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    12
    Author
    Nithianantharajah, J; Balasuriya, GK; Franks, AE; Hill-Yardin, EL
    Date
    2017
    Source Title
    Current Developmental Disorders Reports
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Nithianantharajah, Jess; Hill, Elisa
    Affiliation
    Physiology
    Florey Department of Neuroscience and Mental Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Nithianantharajah, J., Balasuriya, G. K., Franks, A. E. & Hill-Yardin, E. L. (2017). Using Animal Models to Study the Role of the Gut-Brain Axis in Autism.. Curr Dev Disord Rep, 4 (2), pp.28-36. https://doi.org/10.1007/s40474-017-0111-4.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254691
    DOI
    10.1007/s40474-017-0111-4
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488132
    ARC Grant code
    ARC/FT140101327
    Abstract
    PURPOSE OF REVIEW: Individuals with autism spectrum disorders (ASD) commonly also suffer from gastrointestinal (GI) dysfunction; however, few animal model studies have systematically examined both ASD and GI dysfunction. In this review, we highlight studies investigating GI dysfunction and alterations in gut microbiota in animal models of ASD with the aim of determining if routinely used microbiology and enteric neurophysiology assays could expand our understanding of the link between the two. RECENT FINDINGS: Gut-brain axis research is expanding, and several ASD models demonstrate GI dysfunction. The integration of well-established assays for detecting GI dysfunction into standard behavioural testing batteries is needed. SUMMARY: Advances in understanding the role of the gut-brain axis in ASD are emerging; however, we outline standard assays for investigating gut-brain axis function in rodents to strengthen future phenotyping studies. Integrating these findings to the field of animal behaviour is one of the next major challenges in autism research.

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