Using Animal Models to Study the Role of the Gut-Brain Axis in Autism.
AuthorNithianantharajah, J; Balasuriya, GK; Franks, AE; Hill-Yardin, EL
Source TitleCurrent Developmental Disorders Reports
PublisherSpringer Science and Business Media LLC
Florey Department of Neuroscience and Mental Health
Document TypeJournal Article
CitationsNithianantharajah, J., Balasuriya, G. K., Franks, A. E. & Hill-Yardin, E. L. (2017). Using Animal Models to Study the Role of the Gut-Brain Axis in Autism.. Curr Dev Disord Rep, 4 (2), pp.28-36. https://doi.org/10.1007/s40474-017-0111-4.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488132
ARC Grant codeARC/FT140101327
PURPOSE OF REVIEW: Individuals with autism spectrum disorders (ASD) commonly also suffer from gastrointestinal (GI) dysfunction; however, few animal model studies have systematically examined both ASD and GI dysfunction. In this review, we highlight studies investigating GI dysfunction and alterations in gut microbiota in animal models of ASD with the aim of determining if routinely used microbiology and enteric neurophysiology assays could expand our understanding of the link between the two. RECENT FINDINGS: Gut-brain axis research is expanding, and several ASD models demonstrate GI dysfunction. The integration of well-established assays for detecting GI dysfunction into standard behavioural testing batteries is needed. SUMMARY: Advances in understanding the role of the gut-brain axis in ASD are emerging; however, we outline standard assays for investigating gut-brain axis function in rodents to strengthen future phenotyping studies. Integrating these findings to the field of animal behaviour is one of the next major challenges in autism research.
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