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    All-Cause Mortality Risk in Australian Women with Impaired Fasting Glucose and Diabetes

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    Author
    de Abreu, LLF; Holloway, KL; Mohebbi, M; Sajjad, MA; Kotowicz, MA; Pasco, JA
    Date
    2017-01-01
    Source Title
    Journal of Diabetes Research
    Publisher
    HINDAWI LTD
    University of Melbourne Author/s
    Kotowicz, Mark; Pasco, Julie
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    de Abreu, L. L. F., Holloway, K. L., Mohebbi, M., Sajjad, M. A., Kotowicz, M. A. & Pasco, J. A. (2017). All-Cause Mortality Risk in Australian Women with Impaired Fasting Glucose and Diabetes. JOURNAL OF DIABETES RESEARCH, 2017, https://doi.org/10.1155/2017/2042980.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254694
    DOI
    10.1155/2017/2042980
    Abstract
    AIMS: Impaired fasting glucose (IFG) and diabetes are increasing in prevalence worldwide and lead to serious health problems. The aim of this longitudinal study was to investigate the association between impaired fasting glucose or diabetes and mortality over a 10-year period in Australian women. METHODS: This study included 1167 women (ages 20-94 yr) enrolled in the Geelong Osteoporosis Study. Hazard ratios for all-cause mortality in diabetes, IFG, and normoglycaemia were calculated using a Cox proportional hazards model. RESULTS: Women with diabetes were older and had higher measures of adiposity, LDL cholesterol, and triglycerides compared to the IFG and normoglycaemia groups (all p < 0.001). Mortality rate was greater in women with diabetes compared to both the IFG and normoglycaemia groups (HR 1.8; 95% CI 1.3-2.7). Mortality was not different in women with IFG compared to those with normoglycaemia (HR 1.0; 95% CI 0.7-1.4). CONCLUSIONS: This study reports an association between diabetes and all-cause mortality. However, no association was detected between IFG and all-cause mortality. We also showed that mortality in Australian women with diabetes continues to be elevated and women with IFG are a valuable target for prevention of premature mortality associated with diabetes.

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