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dc.contributor.authorLafourcade, A
dc.contributor.authorHis, M
dc.contributor.authorBaglietto, L
dc.contributor.authorBoutron-Ruault, M-C
dc.contributor.authorDossus, L
dc.contributor.authorRondeau, V
dc.date.accessioned2020-12-17T02:59:01Z
dc.date.available2020-12-17T02:59:01Z
dc.date.issued2018-02-09
dc.identifierpii: 10.1186/s12885-018-4076-4
dc.identifier.citationLafourcade, A., His, M., Baglietto, L., Boutron-Ruault, M. -C., Dossus, L. & Rondeau, V. (2018). Factors associated with breast cancer recurrences or mortality and dynamic prediction of death using history of cancer recurrences: the French E3N cohort.. BMC Cancer, 18 (1), pp.171-. https://doi.org/10.1186/s12885-018-4076-4.
dc.identifier.issn1471-2407
dc.identifier.urihttp://hdl.handle.net/11343/254700
dc.description.abstractBACKGROUND: In addition to tumor characteristics and lifestyle factors, cancer relapses are often related to the risk of death but have not been jointly studied. We investigate the prognostic factors of recurrent events and death after a diagnosis of breast cancer and predict individual deaths including a history of recurrences. METHODS: The E3N (Etude Epidémiologique auprès de Femmes de la Mutuelle Générale de l'Education Nationale) study is a prospective cohort study that was initiated in 1990 to investigate factors associated with the most common types of cancer. Overall survival and three types of recurrent events were considered: locoregional recurrence, metastasis, and second primary breast cancer. Recurrent events and death were analyzed using a joint frailty model. RESULTS: The analysis included 4926 women from the E3N cohort diagnosed with a first primary invasive breast cancer between June 1990 and June 2008; during the follow-up, 1334 cases had a recurrence (median time of follow-up is 7.2 years) and 469 women died. Cases with high grade, large tumor size, axillary nodal involvement, and negative estrogen and progesterone receptors had a higher risk of recurrence or death. Furthermore, smoking increased the risk of relapse. For cases with a medium risk profile in terms of tumor characteristics and lifestyle factors, the probability of dying between 5 and 10 years after diagnosis was 6, 20 and 36% for 0, 1 or 2 recurrences within the first 5 years after diagnosis, respectively. CONCLUSIONS: Our study showed the importance of considering baseline lifestyle characteristics and history of relapses to dynamically predict the risk of death in breast cancer cases. Medical experience coupled with an estimate of a patient's survival probability that considers all available information for this patient would enable physicians to make better informed decisions regarding their actions and thus improve clinical output.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleFactors associated with breast cancer recurrences or mortality and dynamic prediction of death using history of cancer recurrences: the French E3N cohort.
dc.typeJournal Article
dc.identifier.doi10.1186/s12885-018-4076-4
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleBMC Cancer
melbourne.source.volume18
melbourne.source.issue1
melbourne.source.pages171-
dc.rights.licenseCC BY
melbourne.elementsid1321419
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807734
melbourne.contributor.authorBaglietto, Laura
dc.identifier.eissn1471-2407
melbourne.accessrightsOpen Access


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