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    fMRI reveals neural activity overlap between adult and infant pain

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    Author
    Goksan, S; Hartley, C; Emery, F; Cockrill, N; Poorun, R; Moultrie, F; Rogers, R; Campbell, J; Sanders, M; Adams, E; ...
    Date
    2015-04-21
    Source Title
    eLife
    Publisher
    ELIFE SCIENCES PUBLICATIONS LTD
    University of Melbourne Author/s
    Jenkinson, Mark
    Affiliation
    Centre for Neuroscience
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Goksan, S., Hartley, C., Emery, F., Cockrill, N., Poorun, R., Moultrie, F., Rogers, R., Campbell, J., Sanders, M., Adams, E., Clare, S., Jenkinson, M., Tracey, I. & Slater, R. (2015). fMRI reveals neural activity overlap between adult and infant pain. ELIFE, 4, https://doi.org/10.7554/eLife.06356.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254730
    DOI
    10.7554/eLife.06356
    Abstract
    Limited understanding of infant pain has led to its lack of recognition in clinical practice. While the network of brain regions that encode the affective and sensory aspects of adult pain are well described, the brain structures involved in infant nociceptive processing are completely unknown, meaning we cannot infer anything about the nature of the infant pain experience. Using fMRI we identified the network of brain regions that are active following acute noxious stimulation in newborn infants, and compared the activity to that observed in adults. Significant infant brain activity was observed in 18 of the 20 active adult brain regions but not in the infant amygdala or orbitofrontal cortex. Brain regions that encode sensory and affective components of pain are active in infants, suggesting that the infant pain experience closely resembles that seen in adults. This highlights the importance of developing effective pain management strategies in this vulnerable population.

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