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    Schizophrenia moderates the relationship between white matter integrity and cognition

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    Author
    Castro-de-Araujo, LFS; Allin, M; Picchioni, MM; Mcdonald, C; Pantelis, C; Kanaan, RAA
    Date
    2018-09-01
    Source Title
    Schizophrenia Research
    Publisher
    ELSEVIER SCIENCE BV
    University of Melbourne Author/s
    Kanaan, Richard; Pantelis, Christos; Araújo, Luís Fernando; De Araujo, Luis Fernando Silva Castro
    Affiliation
    Psychiatry
    Metadata
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    Document Type
    Journal Article
    Citations
    Castro-de-Araujo, L. F. S., Allin, M., Picchioni, M. M., Mcdonald, C., Pantelis, C. & Kanaan, R. A. A. (2018). Schizophrenia moderates the relationship between white matter integrity and cognition. SCHIZOPHRENIA RESEARCH, 199, pp.250-256. https://doi.org/10.1016/j.schres.2018.03.033.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254744
    DOI
    10.1016/j.schres.2018.03.033
    Abstract
    Cognitive impairment is a primary feature of schizophrenia, with alterations in several cognitive domains appearing in the pre-morbid phase of the disorder. White matter microstructure is also affected in schizophrenia and considered to be related to cognition, but the relationship of the two is unclear. As interaction between cognition and white matter structure involves the interplay of several brain structures and cognitive abilities, investigative methods which can examine the interaction of multiple variables are preferred. A multiple-groups structural equation model (SEM) was used to assess the relationship between diffusion tension imaging data (fractional anisotropy of selected white matter tracts) and cognitive abilities of 196 subjects - 135 healthy subjects and 61 patients with schizophrenia. It was found that multiple-indicators, multiple-causes model best fitted the data analysed. Schizophrenia moderated the relation of white matter function on cognition with a large effect size. This paper extends previous work on modelling intelligence within a SEM framework by incorporating neurological elements into the model, and shows that white matter microstructure in patients with schizophrenia interacts with cognitive abilities.

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