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  • Florey Department of Neuroscience and Mental Health
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    Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways.

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    7
    Author
    Watts, ME; Williams, SM; Nithianantharajah, J; Claudianos, C
    Date
    2018-03-27
    Source Title
    Non-Coding RNA
    Publisher
    MDPI AG
    University of Melbourne Author/s
    Nithianantharajah, Jess
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Watts, M. E., Williams, S. M., Nithianantharajah, J. & Claudianos, C. (2018). Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways.. Noncoding RNA, 4 (2), pp.10-10. https://doi.org/10.3390/ncrna4020010.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254758
    DOI
    10.3390/ncrna4020010
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027187
    Abstract
    Hypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditions. Previously we found that miR-210 is also involved in honeybee learning and memory, raising the questions of how neural activity may induce hypoxia-regulated genes and how miR-210 may regulate plasticity in more complex mammalian systems. Using a pull-down approach, we identified 620 unique target genes of miR-210 in humans, among which there was a significant enrichment of age-related neurodegenerative pathways, including Huntington's, Alzheimer's, and Parkinson's diseases. We have also validated that miR-210 directly regulates various identified target genes of interest involved with neuronal plasticity, neurodegenerative diseases, and miR-210-associated cancers. This data suggests a potentially novel mechanism for how metabolic changes may couple plasticity to neuronal activity through hypoxia-regulated genes such as miR-210.

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