Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways.
AuthorWatts, ME; Williams, SM; Nithianantharajah, J; Claudianos, C
Source TitleNon-Coding RNA
University of Melbourne Author/sNithianantharajah, Jess
AffiliationFlorey Department of Neuroscience and Mental Health
Document TypeJournal Article
CitationsWatts, M. E., Williams, S. M., Nithianantharajah, J. & Claudianos, C. (2018). Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways.. Noncoding RNA, 4 (2), pp.10-10. https://doi.org/10.3390/ncrna4020010.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027187
ARC Grant codeARC/FT140101327
Hypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditions. Previously we found that miR-210 is also involved in honeybee learning and memory, raising the questions of how neural activity may induce hypoxia-regulated genes and how miR-210 may regulate plasticity in more complex mammalian systems. Using a pull-down approach, we identified 620 unique target genes of miR-210 in humans, among which there was a significant enrichment of age-related neurodegenerative pathways, including Huntington's, Alzheimer's, and Parkinson's diseases. We have also validated that miR-210 directly regulates various identified target genes of interest involved with neuronal plasticity, neurodegenerative diseases, and miR-210-associated cancers. This data suggests a potentially novel mechanism for how metabolic changes may couple plasticity to neuronal activity through hypoxia-regulated genes such as miR-210.
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