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dc.contributor.authorWatts, ME
dc.contributor.authorWilliams, SM
dc.contributor.authorNithianantharajah, J
dc.contributor.authorClaudianos, C
dc.date.accessioned2020-12-17T03:08:05Z
dc.date.available2020-12-17T03:08:05Z
dc.date.issued2018-03-27
dc.identifierpii: ncrna4020010
dc.identifier.citationWatts, M. E., Williams, S. M., Nithianantharajah, J. & Claudianos, C. (2018). Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways.. Noncoding RNA, 4 (2), pp.10-10. https://doi.org/10.3390/ncrna4020010.
dc.identifier.issn2311-553X
dc.identifier.urihttp://hdl.handle.net/11343/254758
dc.description.abstractHypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditions. Previously we found that miR-210 is also involved in honeybee learning and memory, raising the questions of how neural activity may induce hypoxia-regulated genes and how miR-210 may regulate plasticity in more complex mammalian systems. Using a pull-down approach, we identified 620 unique target genes of miR-210 in humans, among which there was a significant enrichment of age-related neurodegenerative pathways, including Huntington's, Alzheimer's, and Parkinson's diseases. We have also validated that miR-210 directly regulates various identified target genes of interest involved with neuronal plasticity, neurodegenerative diseases, and miR-210-associated cancers. This data suggests a potentially novel mechanism for how metabolic changes may couple plasticity to neuronal activity through hypoxia-regulated genes such as miR-210.
dc.languageeng
dc.publisherMDPI AG
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleHypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways.
dc.typeJournal Article
dc.identifier.doi10.3390/ncrna4020010
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.source.titleNon-Coding RNA
melbourne.source.volume4
melbourne.source.issue2
melbourne.source.pages10-10
melbourne.identifier.arcFT140101327
dc.rights.licenseCC BY
melbourne.elementsid1323331
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027187
melbourne.contributor.authorNithianantharajah, Jess
dc.identifier.eissn2311-553X
melbourne.identifier.fundernameidAUST RESEARCH COUNCIL, FT140101327
melbourne.accessrightsOpen Access


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