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    A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis.

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    Author
    Gass, K; Beau de Rochars, MVE; Boakye, D; Bradley, M; Fischer, PU; Gyapong, J; Itoh, M; Ituaso-Conway, N; Joseph, H; Kyelem, D; ...
    Date
    2012-01
    Source Title
    PLoS Neglected Tropical Diseases
    Publisher
    Public Library of Science (PLoS)
    University of Melbourne Author/s
    Joseph, Hayley
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Gass, K., Beau de Rochars, M. V. E., Boakye, D., Bradley, M., Fischer, P. U., Gyapong, J., Itoh, M., Ituaso-Conway, N., Joseph, H., Kyelem, D., Laney, S. J., Legrand, A. -M., Liyanage, T. S., Melrose, W., Mohammed, K., Pilotte, N., Ottesen, E. A., Plichart, C., Ramaiah, K. ,... Lammie, P. (2012). A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis.. PLoS Negl Trop Dis, 6 (1), pp.e1479-. https://doi.org/10.1371/journal.pntd.0001479.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254778
    DOI
    10.1371/journal.pntd.0001479
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260316
    Abstract
    Successful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when the prevalence levels have decreased to a point that MDA campaigns can be discontinued without the threat of recrudescence. A six-country study was conducted assessing the performance of seven diagnostic tests, including tests for microfilariae (blood smear, PCR), parasite antigen (ICT, Og4C3) and antifilarial antibody (Bm14, PanLF, Urine SXP). One community survey and one school survey were performed in each country. A total of 8,513 people from the six countries participated in the study, 6,443 through community surveys and 2,070 through school surveys. Specimens from these participants were used to conduct 49,585 diagnostic tests. Each test was seen to have both positive and negative attributes, but overall, the ICT test was found to be 76% sensitive at detecting microfilaremia and 93% specific at identifying individuals negative for both microfilariae and antifilarial antibody; the Og4C3 test was 87% sensitive and 95% specific. We conclude, however, that the ICT should be the primary tool recommended for decision-making about stopping MDAs. As a point-of-care diagnostic, the ICT is relatively inexpensive, requires no laboratory equipment, has satisfactory sensitivity and specificity and can be processed in 10 minutes-qualities consistent with programmatic use. Og4C3 provides a satisfactory laboratory-based diagnostic alternative.

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