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dc.contributor.authorGass, K
dc.contributor.authorBeau de Rochars, MVE
dc.contributor.authorBoakye, D
dc.contributor.authorBradley, M
dc.contributor.authorFischer, PU
dc.contributor.authorGyapong, J
dc.contributor.authorItoh, M
dc.contributor.authorItuaso-Conway, N
dc.contributor.authorJoseph, H
dc.contributor.authorKyelem, D
dc.contributor.authorLaney, SJ
dc.contributor.authorLegrand, A-M
dc.contributor.authorLiyanage, TS
dc.contributor.authorMelrose, W
dc.contributor.authorMohammed, K
dc.contributor.authorPilotte, N
dc.contributor.authorOttesen, EA
dc.contributor.authorPlichart, C
dc.contributor.authorRamaiah, K
dc.contributor.authorRao, RU
dc.contributor.authorTalbot, J
dc.contributor.authorWeil, GJ
dc.contributor.authorWilliams, SA
dc.contributor.authorWon, KY
dc.contributor.authorLammie, P
dc.date.accessioned2020-12-17T03:10:53Z
dc.date.available2020-12-17T03:10:53Z
dc.date.issued2012-01
dc.identifierpii: PNTD-D-11-00625
dc.identifier.citationGass, K., Beau de Rochars, M. V. E., Boakye, D., Bradley, M., Fischer, P. U., Gyapong, J., Itoh, M., Ituaso-Conway, N., Joseph, H., Kyelem, D., Laney, S. J., Legrand, A. -M., Liyanage, T. S., Melrose, W., Mohammed, K., Pilotte, N., Ottesen, E. A., Plichart, C., Ramaiah, K. ,... Lammie, P. (2012). A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis.. PLoS Negl Trop Dis, 6 (1), pp.e1479-. https://doi.org/10.1371/journal.pntd.0001479.
dc.identifier.issn1935-2727
dc.identifier.urihttp://hdl.handle.net/11343/254778
dc.description.abstractSuccessful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when the prevalence levels have decreased to a point that MDA campaigns can be discontinued without the threat of recrudescence. A six-country study was conducted assessing the performance of seven diagnostic tests, including tests for microfilariae (blood smear, PCR), parasite antigen (ICT, Og4C3) and antifilarial antibody (Bm14, PanLF, Urine SXP). One community survey and one school survey were performed in each country. A total of 8,513 people from the six countries participated in the study, 6,443 through community surveys and 2,070 through school surveys. Specimens from these participants were used to conduct 49,585 diagnostic tests. Each test was seen to have both positive and negative attributes, but overall, the ICT test was found to be 76% sensitive at detecting microfilaremia and 93% specific at identifying individuals negative for both microfilariae and antifilarial antibody; the Og4C3 test was 87% sensitive and 95% specific. We conclude, however, that the ICT should be the primary tool recommended for decision-making about stopping MDAs. As a point-of-care diagnostic, the ICT is relatively inexpensive, requires no laboratory equipment, has satisfactory sensitivity and specificity and can be processed in 10 minutes-qualities consistent with programmatic use. Og4C3 provides a satisfactory laboratory-based diagnostic alternative.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.titleA multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis.
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pntd.0001479
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titlePLoS Neglected Tropical Diseases
melbourne.source.volume6
melbourne.source.issue1
melbourne.source.pagese1479-
dc.rights.licenseCC BY
melbourne.elementsid1320531
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260316
melbourne.contributor.authorJoseph, Hayley
dc.identifier.eissn1935-2735
melbourne.accessrightsOpen Access


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