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dc.contributor.authorEwer, KJ
dc.contributor.authorO'Hara, GA
dc.contributor.authorDuncan, CJA
dc.contributor.authorCollins, KA
dc.contributor.authorSheehy, SH
dc.contributor.authorReyes-Sandoval, A
dc.contributor.authorGoodman, AL
dc.contributor.authorEdwards, NJ
dc.contributor.authorElias, SC
dc.contributor.authorHalstead, FD
dc.contributor.authorLongley, RJ
dc.contributor.authorRowland, R
dc.contributor.authorPoulton, ID
dc.contributor.authorDraper, SJ
dc.contributor.authorBlagborough, AM
dc.contributor.authorBerrie, E
dc.contributor.authorMoyle, S
dc.contributor.authorWilliams, N
dc.contributor.authorSiani, L
dc.contributor.authorFolgori, A
dc.contributor.authorColloca, S
dc.contributor.authorSinden, RE
dc.contributor.authorLawrie, AM
dc.contributor.authorCortese, R
dc.contributor.authorGilbert, SC
dc.contributor.authorNicosia, A
dc.contributor.authorHill, AVS
dc.date.accessioned2020-12-17T03:11:19Z
dc.date.available2020-12-17T03:11:19Z
dc.date.issued2013-11-01
dc.identifierpii: ncomms3836
dc.identifier.citationEwer, K. J., O'Hara, G. A., Duncan, C. J. A., Collins, K. A., Sheehy, S. H., Reyes-Sandoval, A., Goodman, A. L., Edwards, N. J., Elias, S. C., Halstead, F. D., Longley, R. J., Rowland, R., Poulton, I. D., Draper, S. J., Blagborough, A. M., Berrie, E., Moyle, S., Williams, N., Siani, L. ,... Hill, A. V. S. (2013). Protective CD8(+) T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation. NATURE COMMUNICATIONS, 4 (1), https://doi.org/10.1038/ncomms3836.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/254781
dc.description.abstractInduction of antigen-specific CD8(+) T cells offers the prospect of immunization against many infectious diseases, but no subunit vaccine has induced CD8(+) T cells that correlate with efficacy in humans. Here we demonstrate that a replication-deficient chimpanzee adenovirus vector followed by a modified vaccinia virus Ankara booster induces exceptionally high frequency T-cell responses (median >2400 SFC/10(6) peripheral blood mononuclear cells) to the liver-stage Plasmodium falciparum malaria antigen ME-TRAP. It induces sterile protective efficacy against heterologous strain sporozoites in three vaccinees (3/14, 21%), and delays time to patency through substantial reduction of liver-stage parasite burden in five more (5/14, 36%), P=0.008 compared with controls. The frequency of monofunctional interferon-γ-producing CD8(+) T cells, but not antibodies, correlates with sterile protection and delay in time to patency (P(corrected)=0.005). Vaccine-induced CD8(+) T cells provide protection against human malaria, suggesting that a major limitation of previous vaccination approaches has been the insufficient magnitude of induced T cells.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleProtective CD8(+) T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms3836
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleNature Communications
melbourne.source.volume4
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1320747
melbourne.contributor.authorLongley, Rhea
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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