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dc.contributor.authorChen, Z
dc.contributor.authorKwon, D
dc.contributor.authorJin, Z
dc.contributor.authorMonard, S
dc.contributor.authorTelfer, P
dc.contributor.authorJones, MS
dc.contributor.authorLu, CY
dc.contributor.authorAguilar, RF
dc.contributor.authorHo, DD
dc.contributor.authorMarx, PA
dc.date.accessioned2020-12-17T03:11:38Z
dc.date.available2020-12-17T03:11:38Z
dc.date.issued1998-12-07
dc.identifier.citationChen, Z., Kwon, D., Jin, Z., Monard, S., Telfer, P., Jones, M. S., Lu, C. Y., Aguilar, R. F., Ho, D. D. & Marx, P. A. (1998). Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus.. J Exp Med, 188 (11), pp.2057-2065. https://doi.org/10.1084/jem.188.11.2057.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/254783
dc.description.abstractA homozygous 24-bp deletion (Delta24) was found in the CC chemokine receptor 5 (CCR5) of 11 out of 15 red-capped mangabeys (RCMs), Cercocebus torquatus torquatus, both in Africa and in an American zoo. The CCR5 Delta24 defect encompassed eight amino acids in frame in the fourth transmembrane region. Unexpectedly, RCM-009, one of 11 homozygotes (Delta24CCR5/ Delta24CCR5), was found to be naturally infected with a divergent simian immunodeficiency virus (SIV) strain, which was not R5-tropic, but used CCR2b (R2b) as its major coreceptor. SIVrcmGab1 was the only R2b-tropic SIV among other divergent SIVs tested. Cells transfected with the Delta24 CCR5 did not support entry of R5-tropic SIVmac, SIVcpz, SIVmne, HIV-2, or HIV-1, and were also inactive in signal transduction mediated by beta-chemokines. At 86.6%, the Delta24 allelic frequency was significantly higher than that of the 32-bp deletion found in humans. The Delta24 frequency was 4.1% in 34 sooty mangabeys (SMs), a geographically isolated subspecies that was naturally infected with R5-tropic SIV. Finding identical deletions in two mangabey subspecies separated for 10,000 years or more dates the Delta24 CCR5 deletion as ancient. However, the source of the selective pressure for the high rate of CCR5 deletion in RCMs remains to be determined. The high allelic frequency of the Delta24 CCR5 in RCMs, in comparison to that of SMs, suggests that R2b-tropism may have been acquired by SIVrcm, as an adaptation to CCR5 genetic defects appeared in its host.
dc.languageeng
dc.publisherRockefeller University Press
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleNatural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus.
dc.typeJournal Article
dc.identifier.doi10.1084/jem.188.11.2057
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume188
melbourne.source.issue11
melbourne.source.pages2057-2065
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1320785
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212380
melbourne.contributor.authorMonard, Simon
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


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