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    Neuropsychology and neuroimaging profiles of amyloid-positive versus amyloid-negative amnestic mild cognitive impairment patients.

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    Author
    Tomadesso, C; de La Sayette, V; de Flores, R; Bourgeat, P; Villemagne, VL; Egret, S; Eustache, F; Chételat, G
    Date
    2018
    Source Title
    Alzheimer's & dementia (Amsterdam, Netherlands)
    Publisher
    Wiley
    University of Melbourne Author/s
    Villemagne, Victor
    Affiliation
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Tomadesso, C., de La Sayette, V., de Flores, R., Bourgeat, P., Villemagne, V. L., Egret, S., Eustache, F. & Chételat, G. (2018). Neuropsychology and neuroimaging profiles of amyloid-positive versus amyloid-negative amnestic mild cognitive impairment patients.. Alzheimers Dement (Amst), 10 (1), pp.269-277. https://doi.org/10.1016/j.dadm.2018.02.008.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254791
    DOI
    10.1016/j.dadm.2018.02.008
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956939
    Abstract
    Introduction: Patients with amnestic mild cognitive impairment (aMCI) are heterogeneous as regard to their amyloid status. The present study aimed at highlighting the neuropsychological, brain atrophy, and hypometabolism profiles of amyloid-positive (Aβpos) versus amyloid-negative (Aβneg) aMCI patients. Methods: Forty-four aMCI patients and 24 Aβneg healthy controls underwent neuropsychological, structural magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography scans. Data were compared between groups in specific regions of interest and voxelwise with statistical parametric mapping. Results: When directly comparing Aβpos to Aβneg aMCI, the former had lower performances in episodic memory tests (P = .02 to P < .001) while the latter had worse scores in working memory (P = .01) and language (P < .005). Compared to Aβneg healthy controls, both aMCI subgroups showed similar profiles of atrophy and hypometabolism, with no difference between both aMCI subgroups. Conclusion: In a sample of aMCI patients recruited and scanned in the same center, the main difference at baseline between Aβpos and Aβneg aMCI concerned the neuropsychological profile, but not the structural magnetic resonance imaging or 18F-fluorodeoxyglucose positron emission tomography profiles of brain alterations.

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