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    Amyloid β-associated cognitive decline in the absence of clinical disease progression and systemic illness.

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    14
    Author
    Harrington, KD; Lim, YY; Ames, D; Hassenstab, J; Laws, SM; Martins, RN; Rainey-Smith, S; Robertson, J; Rowe, CC; Salvado, O; ...
    Date
    2017
    Source Title
    Alzheimer's & dementia (Amsterdam, Netherlands)
    Publisher
    Wiley
    University of Melbourne Author/s
    Lim, Yen Ying; Ames, David; Rowe, Christopher; Villemagne, Victor; Masters, Colin; Maruff, Paul; Harrington, Karra; Robertson, Joanne
    Affiliation
    Anatomy and Neuroscience
    Florey Department of Neuroscience and Mental Health
    Psychiatry
    Medicine and Radiology
    Business & Economics
    Metadata
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    Document Type
    Journal Article
    Citations
    Harrington, K. D., Lim, Y. Y., Ames, D., Hassenstab, J., Laws, S. M., Martins, R. N., Rainey-Smith, S., Robertson, J., Rowe, C. C., Salvado, O., Doré, V., Villemagne, V. L., Snyder, P. J., Masters, C. L. & Maruff, P. (2017). Amyloid β-associated cognitive decline in the absence of clinical disease progression and systemic illness.. Alzheimers Dement (Amst), 8 (1), pp.156-164. https://doi.org/10.1016/j.dadm.2017.05.006.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254822
    DOI
    10.1016/j.dadm.2017.05.006
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520957
    Abstract
    INTRODUCTION: High levels of amyloid β (Aβ) are associated with cognitive decline in cognitively normal (CN) older adults. This study investigated the nature of cognitive decline in healthy individuals who did not progress to mild cognitive impairment or dementia. METHOD: Cognition was measured over 72 months and compared between low (Aβ-) and high (Aβ+) CN older adults (n = 335) who did not progress to mild cognitive impairment or dementia and who remained free of severe or uncontrolled systemic illness. RESULTS: Compared to the Aβ- group, the Aβ+ group showed no cognitive impairment at baseline but showed substantial decline in verbal learning, episodic memory, and attention over 72 months. DISCUSSION: Moderate cognitive decline, particularly for learning and memory, was associated with Aβ+ in CN older adults in the absence of clinical disease progression and uncontrolled or serious comorbid illness.

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