Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.
AuthorCannioto, RA; LaMonte, MJ; Kelemen, LE; Risch, HA; Eng, KH; Minlikeeva, AN; Hong, C-C; Szender, JB; Sucheston-Campbell, L; Joseph, JM; ...
Source TitleBritish Journal of Cancer
PublisherSpringer Science and Business Media LLC
University of Melbourne Author/sBaglietto, Laura
AffiliationMelbourne School of Population and Global Health
Document TypeJournal Article
CitationsCannioto, R. A., LaMonte, M. J., Kelemen, L. E., Risch, H. A., Eng, K. H., Minlikeeva, A. N., Hong, C. -C., Szender, J. B., Sucheston-Campbell, L., Joseph, J. M., Berchuck, A., Chang-Claude, J., Cramer, D. W., DeFazio, A., Diergaarde, B., Dörk, T., Doherty, J. A., Edwards, R. P., Fridley, B. L. ,... Moysich, K. B. (2016). Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.. Br J Cancer, 115 (1), pp.95-101. https://doi.org/10.1038/bjc.2016.153.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931371
NHMRC Grant codeNHMRC/400281
BACKGROUND: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. METHODS: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. RESULTS: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. CONCLUSION: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.
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