Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.

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    Author
    Cannioto, RA; LaMonte, MJ; Kelemen, LE; Risch, HA; Eng, KH; Minlikeeva, AN; Hong, C-C; Szender, JB; Sucheston-Campbell, L; Joseph, JM; ...
    Date
    2016-06-28
    Source Title
    British Journal of Cancer
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Baglietto, Laura
    Affiliation
    Melbourne School of Population and Global Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Cannioto, R. A., LaMonte, M. J., Kelemen, L. E., Risch, H. A., Eng, K. H., Minlikeeva, A. N., Hong, C. -C., Szender, J. B., Sucheston-Campbell, L., Joseph, J. M., Berchuck, A., Chang-Claude, J., Cramer, D. W., DeFazio, A., Diergaarde, B., Dörk, T., Doherty, J. A., Edwards, R. P., Fridley, B. L. ,... Moysich, K. B. (2016). Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.. Br J Cancer, 115 (1), pp.95-101. https://doi.org/10.1038/bjc.2016.153.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254840
    DOI
    10.1038/bjc.2016.153
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931371
    Abstract
    BACKGROUND: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. METHODS: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. RESULTS: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. CONCLUSION: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.

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