Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.

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Cannioto, RA; LaMonte, MJ; Kelemen, LE; Risch, HA; Eng, KH; Minlikeeva, AN; Hong, C-C; Szender, JB; Sucheston-Campbell, L; Joseph, JM; ...Date
2016-06-28Source Title
British Journal of CancerPublisher
Springer Science and Business Media LLCUniversity of Melbourne Author/s
Baglietto, LauraAffiliation
Melbourne School of Population and Global HealthMetadata
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Cannioto, R. A., LaMonte, M. J., Kelemen, L. E., Risch, H. A., Eng, K. H., Minlikeeva, A. N., Hong, C. -C., Szender, J. B., Sucheston-Campbell, L., Joseph, J. M., Berchuck, A., Chang-Claude, J., Cramer, D. W., DeFazio, A., Diergaarde, B., Dörk, T., Doherty, J. A., Edwards, R. P., Fridley, B. L. ,... Moysich, K. B. (2016). Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.. Br J Cancer, 115 (1), pp.95-101. https://doi.org/10.1038/bjc.2016.153.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931371Abstract
BACKGROUND: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. METHODS: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. RESULTS: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. CONCLUSION: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.
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