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    Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium.

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    Author
    Nagle, CM; Dixon, SC; Jensen, A; Kjaer, SK; Modugno, F; deFazio, A; Fereday, S; Hung, J; Johnatty, SE; Australian Ovarian Cancer Study Group; ...
    Date
    2015-09-01
    Source Title
    British Journal of Cancer
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Baglietto, Laura
    Affiliation
    Melbourne School of Population and Global Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Nagle, C. M., Dixon, S. C., Jensen, A., Kjaer, S. K., Modugno, F., deFazio, A., Fereday, S., Hung, J., Johnatty, S. E., Australian Ovarian Cancer Study Group, Fasching, P. A., Beckmann, M. W., Lambrechts, D., Vergote, I., Van Nieuwenhuysen, E., Lambrechts, S., Risch, H. A., Rossing, M. A., Doherty, J. A. ,... Ovarian Cancer Association Consortium (2015). Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium.. Br J Cancer, 113 (5), pp.817-826. https://doi.org/10.1038/bjc.2015.245.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254841
    DOI
    10.1038/bjc.2015.245
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559823
    Abstract
    BACKGROUND: Observational studies have reported a modest association between obesity and risk of ovarian cancer; however, whether it is also associated with survival and whether this association varies for the different histologic subtypes are not clear. We undertook an international collaborative analysis to assess the association between body mass index (BMI), assessed shortly before diagnosis, progression-free survival (PFS), ovarian cancer-specific survival and overall survival (OS) among women with invasive ovarian cancer. METHODS: We used original data from 21 studies, which included 12 390 women with ovarian carcinoma. We combined study-specific adjusted hazard ratios (HRs) using random-effects models to estimate pooled HRs (pHR). We further explored associations by histologic subtype. RESULTS: Overall, 6715 (54%) deaths occurred during follow-up. A significant OS disadvantage was observed for women who were obese (BMI: 30-34.9, pHR: 1.10 (95% confidence intervals (CIs): 0.99-1.23); BMI: ⩾35, pHR: 1.12 (95% CI: 1.01-1.25)). Results were similar for PFS and ovarian cancer-specific survival. In analyses stratified by histologic subtype, associations were strongest for women with low-grade serous (pHR: 1.12 per 5 kg m(-2)) and endometrioid subtypes (pHR: 1.08 per 5 kg m(-2)), and more modest for the high-grade serous (pHR: 1.04 per 5 kg m(-2)) subtype, but only the association with high-grade serous cancers was significant. CONCLUSIONS: Higher BMI is associated with adverse survival among the majority of women with ovarian cancer.

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