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    Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.

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    Author
    Dixon, SC; Nagle, CM; Wentzensen, N; Trabert, B; Beeghly-Fadiel, A; Schildkraut, JM; Moysich, KB; deFazio, A; Australian Ovarian Cancer Study Group; Risch, HA; ...
    Date
    2017-04-25
    Source Title
    British Journal of Cancer
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Baglietto, Laura
    Affiliation
    Melbourne School of Population and Global Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Dixon, S. C., Nagle, C. M., Wentzensen, N., Trabert, B., Beeghly-Fadiel, A., Schildkraut, J. M., Moysich, K. B., deFazio, A., Australian Ovarian Cancer Study Group, Risch, H. A., Rossing, M. A., Doherty, J. A., Wicklund, K. G., Goodman, M. T., Modugno, F., Ness, R. B., Edwards, R. P., Jensen, A., Kjær, S. K. ,... Webb, P. M. (2017). Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.. Br J Cancer, 116 (9), pp.1223-1228. https://doi.org/10.1038/bjc.2017.68.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254856
    DOI
    10.1038/bjc.2017.68
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418444
    Abstract
    BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. METHODS: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths). RESULTS: Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88-1.04); non-aspirin NSAIDs 0.97 (0.89-1.05); acetaminophen 1.01 (0.93-1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR=0.89 (0.82-0.98)). CONCLUSIONS: Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted.

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