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dc.contributor.authorEarp, M
dc.contributor.authorWinham, SJ
dc.contributor.authorLarson, N
dc.contributor.authorPermuth, JB
dc.contributor.authorSicotte, H
dc.contributor.authorChien, J
dc.contributor.authorAnton-Culver, H
dc.contributor.authorBandera, EV
dc.contributor.authorBerchuck, A
dc.contributor.authorCook, LS
dc.contributor.authorCramer, D
dc.contributor.authorDoherty, JA
dc.contributor.authorGoodman, MT
dc.contributor.authorLevine, DA
dc.contributor.authorMonteiro, ANA
dc.contributor.authorNess, RB
dc.contributor.authorPearce, CL
dc.contributor.authorRossing, MA
dc.contributor.authorTworoger, SS
dc.contributor.authorWentzensen, N
dc.contributor.authorBisogna, M
dc.contributor.authorBrinton, L
dc.contributor.authorBrooks-Wilson, A
dc.contributor.authorCarney, ME
dc.contributor.authorCunningham, JM
dc.contributor.authorEdwards, RP
dc.contributor.authorFogarty, ZC
dc.contributor.authorIversen, ES
dc.contributor.authorKraft, P
dc.contributor.authorLarson, MC
dc.contributor.authorLe, ND
dc.contributor.authorLin, H-Y
dc.contributor.authorLissowska, J
dc.contributor.authorModugno, F
dc.contributor.authorMoysich, KB
dc.contributor.authorOlson, SH
dc.contributor.authorPike, MC
dc.contributor.authorPoole, EM
dc.contributor.authorRider, DN
dc.contributor.authorTerry, KL
dc.contributor.authorThompson, PJ
dc.contributor.authorvan den Berg, D
dc.contributor.authorVierkant, RA
dc.contributor.authorVitonis, AF
dc.contributor.authorWilkens, LR
dc.contributor.authorWu, AH
dc.contributor.authorYang, HP
dc.contributor.authorZiogas, A
dc.contributor.authorPhelan, CM
dc.contributor.authorSchildkraut, JM
dc.contributor.authorChen, YA
dc.contributor.authorSellers, TA
dc.contributor.authorFridley, BL
dc.contributor.authorGoode, EL
dc.date.accessioned2020-12-17T03:22:19Z
dc.date.available2020-12-17T03:22:19Z
dc.date.issued2016-02-16
dc.identifierpii: 7121
dc.identifier.citationEarp, M., Winham, S. J., Larson, N., Permuth, J. B., Sicotte, H., Chien, J., Anton-Culver, H., Bandera, E. V., Berchuck, A., Cook, L. S., Cramer, D., Doherty, J. A., Goodman, M. T., Levine, D. A., Monteiro, A. N. A., Ness, R. B., Pearce, C. L., Rossing, M. A., Tworoger, S. S. ,... Goode, E. L. (2016). A targeted genetic association study of epithelial ovarian cancer susceptibility.. Oncotarget, 7 (7), pp.7381-7389. https://doi.org/10.18632/oncotarget.7121.
dc.identifier.issn1949-2553
dc.identifier.urihttp://hdl.handle.net/11343/254857
dc.description.abstractBACKGROUND: Genome-wide association studies have identified several common susceptibility alleles for epithelial ovarian cancer (EOC). To further understand EOC susceptibility, we examined previously ungenotyped candidate variants, including uncommon variants and those residing within known susceptibility loci. RESULTS: At nine of eleven previously published EOC susceptibility regions (2q31, 3q25, 5p15, 8q21, 8q24, 10p12, 17q12, 17q21.31, and 19p13), novel variants were identified that were more strongly associated with risk than previously reported variants. Beyond known susceptibility regions, no variants were found to be associated with EOC risk at genome-wide statistical significance (p <5x10(-8)), nor were any significant after Bonferroni correction for 17,000 variants (p< 3x10-6). METHODS: A customized genotyping array was used to assess over 17,000 variants in coding, non-coding, regulatory, and known susceptibility regions in 4,973 EOC cases and 5,640 controls from 13 independent studies. Susceptibility for EOC overall and for select histotypes was evaluated using logistic regression adjusted for age, study site, and population substructure. CONCLUSION: Given the novel variants identified within the 2q31, 3q25, 5p15, 8q21, 8q24, 10p12, 17q12, 17q21.31, and 19p13 regions, larger follow-up genotyping studies, using imputation where necessary, are needed for fine-mapping and confirmation of low frequency variants that fall below statistical significance.
dc.languageeng
dc.publisherImpact Journals, LLC
dc.titleA targeted genetic association study of epithelial ovarian cancer susceptibility.
dc.typeJournal Article
dc.identifier.doi10.18632/oncotarget.7121
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleOncotarget
melbourne.source.volume7
melbourne.source.issue7
melbourne.source.pages7381-7389
dc.rights.licenseCC BY
melbourne.elementsid1324098
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884925
melbourne.contributor.authorBaglietto, Laura
dc.identifier.eissn1949-2553
melbourne.accessrightsOpen Access


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