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dc.contributor.authorCastagné, R
dc.contributor.authorGarès, V
dc.contributor.authorKarimi, M
dc.contributor.authorChadeau-Hyam, M
dc.contributor.authorVineis, P
dc.contributor.authorDelpierre, C
dc.contributor.authorKelly-Irving, M
dc.contributor.authorLifepath Consortium
dc.date.accessioned2020-12-17T03:22:52Z
dc.date.available2020-12-17T03:22:52Z
dc.date.issued2018-05
dc.identifierpii: 10.1007/s10654-018-0364-1
dc.identifier.citationCastagné, R., Garès, V., Karimi, M., Chadeau-Hyam, M., Vineis, P., Delpierre, C., Kelly-Irving, M. & Lifepath Consortium (2018). Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort.. Eur J Epidemiol, 33 (5), pp.441-458. https://doi.org/10.1007/s10654-018-0364-1.
dc.identifier.issn0393-2990
dc.identifier.urihttp://hdl.handle.net/11343/254861
dc.description.abstractThe concept of allostatic load (AL) refers to the idea of a global physiological 'wear and tear' resulting from the adaptation to the environment through the stress response systems over the life span. The link between socioeconomic position (SEP) and mortality has now been established, and there is evidence that AL may capture the link between SEP and mortality. In order to quantitatively assess the role of AL on mortality, we use data from the 1958 British birth cohort including eleven year mortality in 8,113 adults. Specifically, we interrogate the hypothesis of a cumulative biological risk (allostatic load) reflecting 4 physiological systems potentially predicting future risk of death (N = 132). AL was defined using 14 biomarkers assayed in blood from a biosample collected at 44 years of age. Cox proportional hazard regression analysis revealed that higher allostatic load at 44 years old was a significant predictor of mortality 11 years later [HR = 3.56 (2.3 to 5.53)]. We found that this relationship was not solely related to early-life SEP, adverse childhood experiences and young adulthood health status, behaviours and SEP [HR = 2.57 (1.59 to 4.15)]. Regarding the ability of each physiological system and biomarkers to predict future death, our results suggest that the cumulative measure was advantageous compared to evaluating each physiological system sub-score and biomarker separately. Our findings add some evidence of a biological embodiment in response to stress which ultimately affects mortality.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.titleAllostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort.
dc.typeJournal Article
dc.identifier.doi10.1007/s10654-018-0364-1
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleEuropean Journal of Epidemiology
melbourne.source.volume33
melbourne.source.issue5
melbourne.source.pages441-458
dc.rights.licenseCC BY
melbourne.elementsid1324413
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968064
melbourne.contributor.authorGiles, Graham
melbourne.contributor.authorSeveri, Gianluca
dc.identifier.eissn1573-7284
melbourne.accessrightsOpen Access


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