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    Characterising the phenotypic evolution of circulating tumour cells during treatment

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    Author
    Tsao, SC-H; Wang, J; Wang, Y; Behren, A; Cebon, J; Trau, M
    Date
    2018-04-16
    Source Title
    Nature Communications
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Tsao, Chang-Hao; Behren, Andreas; CEBON, JONATHAN
    Affiliation
    Medicine and Radiology
    Surgery (St Vincent's)
    Metadata
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    Document Type
    Journal Article
    Citations
    Tsao, S. C. -H., Wang, J., Wang, Y., Behren, A., Cebon, J. & Trau, M. (2018). Characterising the phenotypic evolution of circulating tumour cells during treatment. NATURE COMMUNICATIONS, 9 (1), https://doi.org/10.1038/s41467-018-03725-8.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254862
    DOI
    10.1038/s41467-018-03725-8
    Abstract
    Real-time monitoring of cancer cells' phenotypic evolution during therapy can provide vital tumour biology information for treatment management. Circulating tumour cell (CTC) analysis has emerged as a useful monitoring tool, but its routine usage is restricted by either limited multiplexing capability or sensitivity. Here, we demonstrate the use of antibody-conjugated and Raman reporter-coated gold nanoparticles for simultaneous labelling and monitoring of multiple CTC surface markers (named as "cell signature"), without the need for isolating individual CTCs. We observe cell heterogeneity and phenotypic changes of melanoma cell lines during molecular targeted treatment. Furthermore, we follow the CTC signature changes of 10 stage-IV melanoma patients receiving immunological or molecular targeted therapies. Our technique maps the phenotypic evolution of patient CTCs sensitively and rapidly, and shows drug-resistant clones having different CTC signatures of potential clinical value. We believe our proposed method is of general interest in the CTC relevant research and translation fields.

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