History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report.

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Minlikeeva, AN; Freudenheim, JL; Cannioto, RA; Eng, KH; Szender, JB; Mayor, P; Etter, JL; Cramer, DW; Diergaarde, B; Doherty, JA; ...Date
2017-09-26Source Title
British Journal of CancerPublisher
Springer Science and Business Media LLCUniversity of Melbourne Author/s
Baglietto, LauraAffiliation
Melbourne School of Population and Global HealthMetadata
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Minlikeeva, A. N., Freudenheim, J. L., Cannioto, R. A., Eng, K. H., Szender, J. B., Mayor, P., Etter, J. L., Cramer, D. W., Diergaarde, B., Doherty, J. A., Dörk, T., Edwards, R., deFazio, A., Friel, G., Goodman, M. T., Hillemanns, P., Høgdall, E., Jensen, A., Jordan, S. J. ,... Moysich, K. B. (2017). History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report.. Br J Cancer, 117 (7), pp.1063-1069. https://doi.org/10.1038/bjc.2017.267.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625672Abstract
BACKGROUND: Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited. METHODS: We pooled data from 11 studies from the Ovarian Cancer Association Consortium. Using multivariate Cox proportional hazards models, we estimated associations between hyper- and hypothyroidism and medications prescribed for these conditions with 5-year all-cause survival among women diagnosed with invasive ovarian cancer. RESULTS: Overall, there was a nonsignificant association with history of hyperthyroidism (n=160 cases) and mortality (HR=1.22; 95% CI=0.97-1.53). Furthermore, diagnosis of hyperthyroidism within the 5 years before ovarian cancer diagnosis was associated with an increased risk of death (HR=1.94; 95% CI=1.19-3.18). A more modest association was observed with history of hypothyroidism (n=624 cases) and mortality (HR=1.16; 95% CI=1.03-1.31). Neither duration of hypothyroidism nor use of thyroid medications was associated with survival. CONCLUSIONS: In this large study of women with ovarian cancer, we found that recent history of hyperthyroidism and overall history of hypothyroidism were associated with worse 5-year survival.
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