Effect of Glutathione Bio-Molecule on Tooth Discoloration Associated with Silver Diammine Fluoride
AuthorSayed, M; Matsui, N; Hiraishi, N; Nikaido, T; Burrow, MF; Tagami, J
Source TitleInternational Journal of Molecular Sciences
University of Melbourne Author/sBurrow, Michael
AffiliationMelbourne Dental School
Document TypeJournal Article
CitationsSayed, M., Matsui, N., Hiraishi, N., Nikaido, T., Burrow, M. F. & Tagami, J. (2018). Effect of Glutathione Bio-Molecule on Tooth Discoloration Associated with Silver Diammine Fluoride. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19 (5), https://doi.org/10.3390/ijms19051322.
Access StatusOpen Access
This study evaluated the effect of Glutathione (GSH) bio-molecule on the reduction of enamel and dentin discoloration after application of 38% silver diammine fluoride solution (SDF). One hundred and twenty bovine teeth specimens were used. The enamel and dentin specimens were divided into three groups: (1) SDF only (control); (2) SDF followed by application of a potassium iodide solution (KI); and (3) SDF mixed with 20% GSH. Half the specimens were exposed to light and the remainder kept in dark conditions (n = 10) Color changes were measured using a spectrophotometer at the following time intervals: before solution application (baseline) and immediately after application, then 3, 6, 24, 48, 72 h, and 7, 10 and 14 days. SEM/EDS analysis was performed on treated enamel and dentin. Statistical analysis was done using a repeated measures ANOVA test. The spectrophotometer results showed that the SDF group exhibited the greatest color changes under both light exposed and dark conditions, while SDF + GSH group was effective in decreasing the color changes in both light and dark conditions. The SDF + KI group showed an insignificant color changes over time. SEM/EDS analysis showed different patterns for the silver crystal formation in each group (SDF, SDF + GSH, and SDF + KI group). It was concluded GSH can effectively minimize color changes after application of SDF, especially on enamel and to a lesser extent on dentin.
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