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dc.contributor.authorSayed, M
dc.contributor.authorMatsui, N
dc.contributor.authorHiraishi, N
dc.contributor.authorNikaido, T
dc.contributor.authorBurrow, MF
dc.contributor.authorTagami, J
dc.date.accessioned2020-12-17T03:26:15Z
dc.date.available2020-12-17T03:26:15Z
dc.date.issued2018-05-01
dc.identifierpii: ijms19051322
dc.identifier.citationSayed, M., Matsui, N., Hiraishi, N., Nikaido, T., Burrow, M. F. & Tagami, J. (2018). Effect of Glutathione Bio-Molecule on Tooth Discoloration Associated with Silver Diammine Fluoride. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19 (5), https://doi.org/10.3390/ijms19051322.
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11343/254885
dc.description.abstractThis study evaluated the effect of Glutathione (GSH) bio-molecule on the reduction of enamel and dentin discoloration after application of 38% silver diammine fluoride solution (SDF). One hundred and twenty bovine teeth specimens were used. The enamel and dentin specimens were divided into three groups: (1) SDF only (control); (2) SDF followed by application of a potassium iodide solution (KI); and (3) SDF mixed with 20% GSH. Half the specimens were exposed to light and the remainder kept in dark conditions (n = 10) Color changes were measured using a spectrophotometer at the following time intervals: before solution application (baseline) and immediately after application, then 3, 6, 24, 48, 72 h, and 7, 10 and 14 days. SEM/EDS analysis was performed on treated enamel and dentin. Statistical analysis was done using a repeated measures ANOVA test. The spectrophotometer results showed that the SDF group exhibited the greatest color changes under both light exposed and dark conditions, while SDF + GSH group was effective in decreasing the color changes in both light and dark conditions. The SDF + KI group showed an insignificant color changes over time. SEM/EDS analysis showed different patterns for the silver crystal formation in each group (SDF, SDF + GSH, and SDF + KI group). It was concluded GSH can effectively minimize color changes after application of SDF, especially on enamel and to a lesser extent on dentin.
dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEffect of Glutathione Bio-Molecule on Tooth Discoloration Associated with Silver Diammine Fluoride
dc.typeJournal Article
dc.identifier.doi10.3390/ijms19051322
melbourne.affiliation.departmentMelbourne Dental School
melbourne.source.titleInternational Journal of Molecular Sciences
melbourne.source.volume19
melbourne.source.issue5
dc.rights.licenseCC BY
melbourne.elementsid1325834
melbourne.contributor.authorBurrow, Michael
dc.identifier.eissn1422-0067
melbourne.accessrightsOpen Access


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