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dc.contributor.authorZhang, S
dc.contributor.authorChen, W
dc.contributor.authorTang, H
dc.contributor.authorHan, Q
dc.contributor.authorYan, S
dc.contributor.authorZhang, X
dc.contributor.authorChen, Q
dc.contributor.authorParsons, M
dc.contributor.authorWang, S
dc.contributor.authorLou, M
dc.date.accessioned2020-12-17T03:30:09Z
dc.date.available2020-12-17T03:30:09Z
dc.date.issued2016
dc.identifierpii: PONE-D-16-07333
dc.identifier.citationZhang, S., Chen, W., Tang, H., Han, Q., Yan, S., Zhang, X., Chen, Q., Parsons, M., Wang, S. & Lou, M. (2016). The Prognostic Value of a Four-Dimensional CT Angiography-Based Collateral Grading Scale for Reperfusion Therapy in Acute Ischemic Stroke Patients.. PLoS One, 11 (8), pp.e0160502-. https://doi.org/10.1371/journal.pone.0160502.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/254913
dc.description.abstractOBJECTIVE: Leptomeningeal collaterals, which affects tissue fate, are still challenging to assess. Four-dimensional CT angiography (4D CTA) originated from CT perfusion (CTP) provides the possibility of non-invasive and time-resolved assessment of leptomeningeal collateral flow. We sought to develop a comprehensive rating system to integrate the speed and extent of collateral flow on 4D CTA, and investigate its prognostic value for reperfusion therapy in acute ischemic stroke (AIS) patients. METHODS: We retrospectively studied 80 patients with M1 ± internal carotid artery (ICA) occlusion who had baseline CTP before intravenous thrombolysis. The velocity and extent of collaterals were evaluated by regional leptomeningeal collateral score on peak phase (rLMC-P) and temporally fused intensity projections (tMIP) (rLMC-M) on 4D CTA, respectively. The cutoffs of rLMC-P and rLMC-M score for predicting good outcome (mRS score ≤ 2) were integrated to develop the collateral grading scale (CGS) (rating from 0-2). RESULTS: The CGS score was correlated with 3-months mRS score (non-recanalizers: ρ = -0.495, p = 0.01; recanalizers: ρ = -0.671, p < 0.001). Patients with intermediate or good collaterals (CGS score of 1 and 2) who recanalized were more likely to have good outcome than those without recanalization (p = 0.038, p = 0.018), while there was no significant difference in outcome in patients with poor collaterals (CGS score of 0) stratified by recanalization (p = 0.227). CONCLUSIONS: Identification of collaterals based on CGS may help to select good responders to reperfusion therapy in patients with large artery occlusion.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThe Prognostic Value of a Four-Dimensional CT Angiography-Based Collateral Grading Scale for Reperfusion Therapy in Acute Ischemic Stroke Patients.
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0160502
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titlePLoS One
melbourne.source.volume11
melbourne.source.issue8
melbourne.source.pagese0160502-
dc.rights.licenseCC BY
melbourne.elementsid1225795
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978390
melbourne.contributor.authorParsons, Mark
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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