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dc.contributor.authorZhang, S
dc.contributor.authorChen, W
dc.contributor.authorTang, H
dc.contributor.authorHan, Q
dc.contributor.authorYan, S
dc.contributor.authorZhang, X
dc.contributor.authorChen, Q
dc.contributor.authorParsons, M
dc.contributor.authorWang, S
dc.contributor.authorLou, M
dc.date.accessioned2020-12-17T03:30:09Z
dc.date.available2020-12-17T03:30:09Z
dc.date.issued2016
dc.identifierpii: PONE-D-16-07333
dc.identifier.citationZhang, S., Chen, W., Tang, H., Han, Q., Yan, S., Zhang, X., Chen, Q., Parsons, M., Wang, S. & Lou, M. (2016). The Prognostic Value of a Four-Dimensional CT Angiography-Based Collateral Grading Scale for Reperfusion Therapy in Acute Ischemic Stroke Patients.. PLoS One, 11 (8), pp.e0160502-. https://doi.org/10.1371/journal.pone.0160502.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/254913
dc.description.abstractOBJECTIVE: Leptomeningeal collaterals, which affects tissue fate, are still challenging to assess. Four-dimensional CT angiography (4D CTA) originated from CT perfusion (CTP) provides the possibility of non-invasive and time-resolved assessment of leptomeningeal collateral flow. We sought to develop a comprehensive rating system to integrate the speed and extent of collateral flow on 4D CTA, and investigate its prognostic value for reperfusion therapy in acute ischemic stroke (AIS) patients. METHODS: We retrospectively studied 80 patients with M1 ± internal carotid artery (ICA) occlusion who had baseline CTP before intravenous thrombolysis. The velocity and extent of collaterals were evaluated by regional leptomeningeal collateral score on peak phase (rLMC-P) and temporally fused intensity projections (tMIP) (rLMC-M) on 4D CTA, respectively. The cutoffs of rLMC-P and rLMC-M score for predicting good outcome (mRS score ≤ 2) were integrated to develop the collateral grading scale (CGS) (rating from 0-2). RESULTS: The CGS score was correlated with 3-months mRS score (non-recanalizers: ρ = -0.495, p = 0.01; recanalizers: ρ = -0.671, p < 0.001). Patients with intermediate or good collaterals (CGS score of 1 and 2) who recanalized were more likely to have good outcome than those without recanalization (p = 0.038, p = 0.018), while there was no significant difference in outcome in patients with poor collaterals (CGS score of 0) stratified by recanalization (p = 0.227). CONCLUSIONS: Identification of collaterals based on CGS may help to select good responders to reperfusion therapy in patients with large artery occlusion.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.titleThe Prognostic Value of a Four-Dimensional CT Angiography-Based Collateral Grading Scale for Reperfusion Therapy in Acute Ischemic Stroke Patients.
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0160502
melbourne.affiliation.departmentMedicine and Radiology
melbourne.source.titlePLoS One
melbourne.source.volume11
melbourne.source.issue8
melbourne.source.pagese0160502-
dc.rights.licenseCC BY
melbourne.elementsid1225795
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978390
melbourne.contributor.authorParsons, Mark
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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