Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder
AuthorBarbosa, IG; Vaz, GN; Rocha, NP; Machado-Vieira, R; Diniz Ventura, MR; Huguet, RB; Bauer, ME; Berk, M; Teixeira, AL
Source TitleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
PublisherKOREAN COLL NEUROPSYCHOPHARMACOLOGY
University of Melbourne Author/sBerk, Michael
Document TypeJournal Article
CitationsBarbosa, I. G., Vaz, G. N., Rocha, N. P., Machado-Vieira, R., Diniz Ventura, M. R., Huguet, R. B., Bauer, M. E., Berk, M. & Teixeira, A. L. (2017). Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder. CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, 15 (3), pp.269-275. https://doi.org/10.9758/cpn.2017.15.3.269.
Access StatusOpen Access
Objective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD. Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type 1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA. Results: Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls. Conclusion: These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.
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