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dc.contributor.authorBarbosa, IG
dc.contributor.authorVaz, GN
dc.contributor.authorRocha, NP
dc.contributor.authorMachado-Vieira, R
dc.contributor.authorDiniz Ventura, MR
dc.contributor.authorHuguet, RB
dc.contributor.authorBauer, ME
dc.contributor.authorBerk, M
dc.contributor.authorTeixeira, AL
dc.date.accessioned2020-12-17T03:32:20Z
dc.date.available2020-12-17T03:32:20Z
dc.date.issued2017-08-01
dc.identifierpii: cpn.2017.15.3.269
dc.identifier.citationBarbosa, I. G., Vaz, G. N., Rocha, N. P., Machado-Vieira, R., Diniz Ventura, M. R., Huguet, R. B., Bauer, M. E., Berk, M. & Teixeira, A. L. (2017). Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder. CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, 15 (3), pp.269-275. https://doi.org/10.9758/cpn.2017.15.3.269.
dc.identifier.issn1738-1088
dc.identifier.urihttp://hdl.handle.net/11343/254926
dc.description.abstractObjective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD. Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type 1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA. Results: Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls. Conclusion: These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.
dc.languageEnglish
dc.publisherKOREAN COLL NEUROPSYCHOPHARMACOLOGY
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titlePlasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder
dc.typeJournal Article
dc.identifier.doi10.9758/cpn.2017.15.3.269
melbourne.affiliation.departmentPsychiatry
melbourne.source.titleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
melbourne.source.volume15
melbourne.source.issue3
melbourne.source.pages269-275
dc.rights.licenseCC BY-NC
melbourne.elementsid1229221
melbourne.contributor.authorBerk, Michael
dc.identifier.eissn2093-4327
melbourne.accessrightsOpen Access


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