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    Circular RNAs: Isolation, characterization and their potential role in diseases

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    Author
    Liu, L; Wang, J; Khanabdali, R; Kalionis, B; Tai, X; Xia, S
    Date
    2017-01-01
    Source Title
    RNA Biology
    Publisher
    TAYLOR & FRANCIS INC
    University of Melbourne Author/s
    Kalionis, Bill; Khanabdali, Ramin
    Affiliation
    Obstetrics and Gynaecology
    Metadata
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    Document Type
    Journal Article
    Citations
    Liu, L., Wang, J., Khanabdali, R., Kalionis, B., Tai, X. & Xia, S. (2017). Circular RNAs: Isolation, characterization and their potential role in diseases. RNA BIOLOGY, 14 (12), pp.1715-1721. https://doi.org/10.1080/15476286.2017.1367886.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254933
    DOI
    10.1080/15476286.2017.1367886
    Abstract
    Circular RNA (circRNA) generated by alternative splicing represents a special class of non-coding RNA molecule. CircRNAs are abundant in the eukaryotic cell cytoplasm and have a characteristic organization, timing of action and disease specificity. In contrast to linear RNA, circRNAs are resistant to RNA exonuclease. Consequently, circRNA escapes normal RNA turnover and this improves circRNA stability. CircRNAs can be degraded by microRNA (miRNA) and this results in linearization of the circRNA, which can then act as competitor to endogenous RNA. Through interactions with disease-related miRNA, circRNA can play an important regulatory role in specific diseases. Furthermore, circRNAs have significant potential to become new clinical diagnostic markers.

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