Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination
AuthorDe La Fuente, AG; Lange, S; Silva, ME; Gonzalez, GA; Tempfer, H; van Wijngaarden, P; Zhao, C; Di Canio, L; Trost, A; Bieler, L; ...
Source TitleCell Reports
University of Melbourne Author/svan Wijngaarden, Peter
AffiliationOphthalmology (Eye & Ear Hospital)
Document TypeJournal Article
CitationsDe La Fuente, A. G., Lange, S., Silva, M. E., Gonzalez, G. A., Tempfer, H., van Wijngaarden, P., Zhao, C., Di Canio, L., Trost, A., Bieler, L., Zaunmair, P., Rotheneichner, P., O'Sullivan, A., Couillard-Despres, S., Errea, O., Mae, M. A., Andrae, J., He, L., Keller, A. ,... Rivera, F. J. (2017). Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination. CELL REPORTS, 20 (8), pp.1755-1764. https://doi.org/10.1016/j.celrep.2017.08.007.
Access StatusOpen Access
NHMRC Grant codeNHMRC/628928
The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfbret/ret mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded to completion. PC-conditioned medium accelerated and enhanced OPC differentiation in vitro and increased the rate of remyelination in an ex vivo cerebellar slice model of demyelination. We identified Lama2 as a PC-derived factor that promotes OPC differentiation. Thus, the functional role of PCs is not restricted to vascular homeostasis but includes the modulation of adult CNS progenitor cells involved in regeneration.
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