Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

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    Author
    De La Fuente, AG; Lange, S; Silva, ME; Gonzalez, GA; Tempfer, H; van Wijngaarden, P; Zhao, C; Di Canio, L; Trost, A; Bieler, L; ...
    Date
    2017-08-22
    Source Title
    Cell Reports
    Publisher
    CELL PRESS
    University of Melbourne Author/s
    van Wijngaarden, Peter
    Affiliation
    Ophthalmology (Eye & Ear Hospital)
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    Document Type
    Journal Article
    Citations
    De La Fuente, A. G., Lange, S., Silva, M. E., Gonzalez, G. A., Tempfer, H., van Wijngaarden, P., Zhao, C., Di Canio, L., Trost, A., Bieler, L., Zaunmair, P., Rotheneichner, P., O'Sullivan, A., Couillard-Despres, S., Errea, O., Mae, M. A., Andrae, J., He, L., Keller, A. ,... Rivera, F. J. (2017). Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination. CELL REPORTS, 20 (8), pp.1755-1764. https://doi.org/10.1016/j.celrep.2017.08.007.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254935
    DOI
    10.1016/j.celrep.2017.08.007
    Abstract
    The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfbret/ret mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded to completion. PC-conditioned medium accelerated and enhanced OPC differentiation in vitro and increased the rate of remyelination in an ex vivo cerebellar slice model of demyelination. We identified Lama2 as a PC-derived factor that promotes OPC differentiation. Thus, the functional role of PCs is not restricted to vascular homeostasis but includes the modulation of adult CNS progenitor cells involved in regeneration.

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