Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

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De La Fuente, AG; Lange, S; Silva, ME; Gonzalez, GA; Tempfer, H; van Wijngaarden, P; Zhao, C; Di Canio, L; Trost, A; Bieler, L; ...Date
2017-08-22Source Title
Cell ReportsPublisher
CELL PRESSUniversity of Melbourne Author/s
van Wijngaarden, PeterAffiliation
Ophthalmology (Eye & Ear Hospital)Metadata
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De La Fuente, A. G., Lange, S., Silva, M. E., Gonzalez, G. A., Tempfer, H., van Wijngaarden, P., Zhao, C., Di Canio, L., Trost, A., Bieler, L., Zaunmair, P., Rotheneichner, P., O'Sullivan, A., Couillard-Despres, S., Errea, O., Mae, M. A., Andrae, J., He, L., Keller, A. ,... Rivera, F. J. (2017). Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination. CELL REPORTS, 20 (8), pp.1755-1764. https://doi.org/10.1016/j.celrep.2017.08.007.Access Status
Open AccessAbstract
The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfbret/ret mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded to completion. PC-conditioned medium accelerated and enhanced OPC differentiation in vitro and increased the rate of remyelination in an ex vivo cerebellar slice model of demyelination. We identified Lama2 as a PC-derived factor that promotes OPC differentiation. Thus, the functional role of PCs is not restricted to vascular homeostasis but includes the modulation of adult CNS progenitor cells involved in regeneration.
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